DegronMD

Uniprot ID: Q9H5V7

Source protein: Zinc finger protein Pegasus

Source gene: IKZF5

Class: DEG_APCC_DBOX_1

Location: 192:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.529

ASA_SCORE: 90.7667

COIL: 0.6898

CONS_SCORE: 0.56

DSS_SCORE: 0.3578

HELIX: 0.2538

FCONS_SCORE: 1.0181

RIG_SCORE: 0.7766

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D210Y	TCGA-04-1651	OV	TCGA	SRRALINLS	DEG_APCC_DBOX_1	0.0556
p.D210Y	DO27983	OV	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.0556
p.S192R	TCGA-05-4250	LUAD	TCGA	SRRALINLS	DEG_APCC_DBOX_1	0.6316
p.S192R	DO229029	LICA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.6316
p.S192R	DO24457	LUAD	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.6316
p.R193T	TCGA-44-5644	LUAD	TCGA	SRRALINLS	DEG_APCC_DBOX_1	0.7876
p.R193T	DO25153	LUAD	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.7876
p.P201L	TCGA-D3-A2JL	SKCM	TCGA	SRRALINLS	DEG_APCC_DBOX_1	0.3056
p.P201L	DO47278	SKCM	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.3056
p.L199V	DO223020	ESCA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.5654
p.P209T	DO229022	LICA	ICGC	SRRALINLS	DEG_APCC_DBOX_1	0.0833
p.S187N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRRALINLS	DEG_APCC_DBOX_1	0.1944
p.S187N	ACH-002256	Leukemia	CCLE	SRRALINLS	DEG_APCC_DBOX_1	0.1944
p.S187N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRRALINLS	DEG_APCC_DBOX_1	0.1944
p.P202H	SIDM00820	Kidney Carcinoma	GDSC	SRRALINLS	DEG_APCC_DBOX_1	0.2778
p.P202H	ACH-002188	Kidney Cancer	CCLE	SRRALINLS	DEG_APCC_DBOX_1	0.2778
p.P202H	RCC-ER	kidney	COSMIC	SRRALINLS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H5V7	Zinc finger protein Pegasus	DEG_APCC_DBOX_1	192:200	SRRALINLS	APC,CDC20,FZR1	0.529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons