DegronMD

Uniprot ID: Q9H5V7

Source protein: Zinc finger protein Pegasus

Source gene: IKZF5

Class: DEG_SPOP_SBC_1

Location: 336:340

E3 ligase: SPOP

DEGRON score: 0.6143

ASA_SCORE: 65.86

COIL: 0.5728

CONS_SCORE: 0.4655

DSS_SCORE: 0.7914

HELIX: 0.012

FCONS_SCORE: 0.8103

RIG_SCORE: 0.5222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V327A	TCGA-AN-A046	BRCA	TCGA	AHTST	DEG_SPOP_SBC_1	0.0833
p.V327A	DO1285	BRCA	ICGC	AHTST	DEG_SPOP_SBC_1	0.0833
p.P334A	TCGA-D8-A1XK	BRCA	TCGA	AHTST	DEG_SPOP_SBC_1	0.2778
p.P334A	DO4749	BRCA	ICGC	AHTST	DEG_SPOP_SBC_1	0.2778
p.P330T	DO228952	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.1667
p.P348Q	DO228974	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.1111
p.P326Q	DO229019	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.0556
p.S342R	DO229036	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.2778
p.T338K	DO229037	LICA	ICGC	AHTST	DEG_SPOP_SBC_1	0.7306
p.S346G	DO229211	THCA	ICGC	AHTST	DEG_SPOP_SBC_1	0.1667
p.P348S	SIDM00217	Colorectal Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	0.1111
p.P348S	SIDM00980	Gastric Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	0.1111
p.P348S	ACH-000948	Gastric Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	0.1111
p.P348S	ACH-000999	Colon/Colorectal Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	0.1111
p.P348S	23132-87	stomach	COSMIC	AHTST	DEG_SPOP_SBC_1	0.1111
p.P348S	SNU-1040	large_intestine	COSMIC	AHTST	DEG_SPOP_SBC_1	0.1111
p.S349G	ACH-001664	Gastric Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons