DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3831:3835

E3 ligase: SPOP

DEGRON score: 0.9663

ASA_SCORE: 86.2

COIL: 0.7872

CONS_SCORE: 0.2707

DSS_SCORE: 0.6524

HELIX: 0.0348

FCONS_SCORE: 0.9324

RIG_SCORE: 0.7175

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3841V	TCGA-D9-A6EC	SKCM	TCGA	AHTST	DEG_SPOP_SBC_1	0.1667
p.H3832Q	TCGA-DD-AADY	LIHC	TCGA	AHTST	DEG_SPOP_SBC_1	0.647
p.H3832R	TCGA-EO-A22X	UCEC	TCGA	AHTST	DEG_SPOP_SBC_1	0.7133
p.M3822R	DO51907	BLCA	ICGC	AHTST	DEG_SPOP_SBC_1	0.0833
p.A3834V	DO228007	LAML	ICGC	AHTST	DEG_SPOP_SBC_1	0.6936
p.A3834V	DO231117	LAML	ICGC	AHTST	DEG_SPOP_SBC_1	0.6936
p.H3835Q	DO52251	LIHC	ICGC	AHTST	DEG_SPOP_SBC_1	0.7582
p.A3844V	DO50291	SKCM	ICGC	AHTST	DEG_SPOP_SBC_1	0.0833
p.H3835R	DO43907	UCEC	ICGC	AHTST	DEG_SPOP_SBC_1	0.8244
p.A3841T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	0.1667
p.T3823I	SIDM00948	Burkitt's Lymphoma	GDSC	AHTST	DEG_SPOP_SBC_1	0.1111
p.T3823I	ACH-002232	Lymphoma	CCLE	AHTST	DEG_SPOP_SBC_1	0.1111
p.T3823I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	AHTST	DEG_SPOP_SBC_1	0.1111
p.T3842I	SIDM00150	Colorectal Carcinoma	GDSC	AHTST	DEG_SPOP_SBC_1	0.1389
p.T3842I	ACH-000969	Colon/Colorectal Cancer	CCLE	AHTST	DEG_SPOP_SBC_1	0.1389
p.T3842I	KM12	large_intestine	COSMIC	AHTST	DEG_SPOP_SBC_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons