DegronMD

Uniprot ID: Q8N307

Source protein: Mucin-20

Source gene: MUC20

Class: DEG_APCC_DBOX_1

Location: 603:611

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9916

ASA_SCORE: 100.2556

COIL: 0.9672

CONS_SCORE: 0.5435

DSS_SCORE: 0.73

HELIX: 0.0101

FCONS_SCORE: 1.0558

RIG_SCORE: 0.6223

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R619Q	TCGA-4Z-AA7R	BLCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	TCGA-K4-A54R	BLCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	DO51866	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	DO48611	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	DO222455	ESCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	SIDM00963	Breast Carcinoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.R619Q	BT-474	breast	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.P606R	TCGA-63-A5MU	LUSC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.6401
p.P606R	DO219165	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6401
p.D593E	TCGA-A5-A0G1	UCEC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.0556
p.D593E	DO42472	UCEC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0556
p.S617N	TCGA-D1-A103	UCEC	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.1667
p.S617N	DO42312	UCEC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1667
p.P608S	TCGA-D3-A8GI	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	TCGA-W3-A824	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	DO50284	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	DO51271	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	SIDM01175	Other Sarcomas	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	ACH-002309	Sarcoma	CCLE	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P608S	SW684	soft_tissue	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.P599R	TCGA-DJ-A3VI	THCA	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.2222
p.P599R	DO223938	THCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.2222
p.T596I	TCGA-EE-A29B	SKCM	TCGA	SRDPLPSVP	DEG_APCC_DBOX_1	0.1389
p.T596I	DO47255	SKCM	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1389
p.A595T	DO48422	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229013	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229016	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229003	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229005	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO230659	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO231140	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO52365	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO231022	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO231189	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229456	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.A595T	DO229515	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.D605A	DO48410	BLCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO228483	BRCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO224731	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO222782	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO222866	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO229010	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO229005	COCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO225404	LAML	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO52365	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO52357	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO52359	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.D605A	DO218843	SKCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6682
p.G620V	DO222955	BTCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.P611S	DO234177	ESAD	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.5641
p.R619L	DO45127	LIRI	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1111
p.G598V	DO231049	LUSC	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1944
p.S609F	DO222567	MELA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.6871
p.G620R	DO232812	PBCA	ICGC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.I594M	SIDM00656	Burkitt's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.I594M	SIDM00641	Burkitt's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.I594M	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.I594V	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRDPLPSVP	DEG_APCC_DBOX_1	0.0833
p.T617A	NB7	autonomic_ganglia	COSMIC	SRDPLPSVP	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRDPLPSVP

Degron related mutations and impact score

Drug responses associated with MUC20 mutations

All proteins holding degron of SRDPLPSVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N307	Mucin-20	DEG_APCC_DBOX_1	603:611	SRDPLPSVP	APC,CDC20,FZR1	0.9916	More...