DegronMD

Uniprot ID: Q8N307

Source protein: Mucin-20

Source gene: MUC20

Class: DEG_SCF_FBW7_1

Location: 394:401

E3 ligase: FBXW7

DEGRON score: 0.9261

ASA_SCORE: 89.5625

COIL: 0.9596

CONS_SCORE: 0.5519

DSS_SCORE: 0.5563

HELIX: 0.0116

FCONS_SCORE: 0.833

RIG_SCORE: 0.6665

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D390N	TCGA-AA-A010	COAD	TCGA	PVITPSWS	DEG_SCF_FBW7_1	0.2222
p.A387T	TCGA-B5-A0JY	UCEC	TCGA	PVITPSWS	DEG_SCF_FBW7_1	0.1389
p.A387T	DO43041	UCEC	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.1389
p.P394A	DO44097	BLCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.7503
p.G391S	DO225139	BRCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO224645	COCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO222826	COCA	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO229354	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO51022	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO51004	LAML	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO224551	LUSC	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO228665	PRAD	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.G391S	DO228725	PRAD	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.25
p.S399P	DO52713	CLLE	ICGC	PVITPSWS	DEG_SCF_FBW7_1	0.5641
p.W400C	SIDM00318	Kidney Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	0.5889
p.W400C	SIDM01139	Pancreatic Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	0.5889
p.W400C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	0.5889
p.W400C	SIDM01066	Melanoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	0.5889
p.W400C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	PVITPSWS	DEG_SCF_FBW7_1	0.5889
p.P402L	HCC1569	breast	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	MDA-MB-157	breast	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	NCI-H835	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	NCI-H748	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	NB13	autonomic_ganglia	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	RKO	large_intestine	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.P402L	NCI-H2110	lung	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.3056
p.L409F	HN	upper_aerodigestive_tract	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.1111
p.S399F	Hep_3B2_1-7	NS	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.6871
p.D408N	WM278	skin	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.1389
p.T392I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.2778
p.V406A	KYSE-150	oesophagus	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.1944
p.A396S	Becker	central_nervous_system	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.7588
p.A408T	SCC-4	upper_aerodigestive_tract	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.1389
p.S390N	RPMI-6666	haematopoietic_and_lymphoid_tissue	COSMIC	PVITPSWS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVITPSWS

Degron related mutations and impact score

Drug responses associated with MUC20 mutations

All proteins holding degron of PVITPSWS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N307	Mucin-20	DEG_SCF_FBW7_1	394:401	PVITPSWS	FBXW7	0.9261	More...