DegronMD

Uniprot ID: Q8N307

Source protein: Mucin-20

Source gene: MUC20

Class: DEG_SPOP_SBC_1

Location: 452:456

E3 ligase: SPOP

DEGRON score: 0.9768

ASA_SCORE: 81.94

COIL: 0.9464

CONS_SCORE: 0.5746

DSS_SCORE: 0.6754

HELIX: 0.0156

FCONS_SCORE: 0.9581

RIG_SCORE: 0.603

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S456F	TCGA-A5-A0G2	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.7982
p.S456F	DO41235	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.7982
p.E466K	TCGA-AC-A23H	BRCA	TCGA	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466K	DO2401	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466K	DO221548	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466K	DO232532	PBCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466K	DO218861	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466K	ACH-001132	Lymphoma	CCLE	ASSTS	DEG_SPOP_SBC_1	0.0556
p.L461M	TCGA-AJ-A3EK	UCEC	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L461M	DO41584	UCEC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.S453L	TCGA-CM-5861	COAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.6556
p.S453L	DO7918	COAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.6556
p.S453L	ACH-001864	Bile Duct Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.6556
p.L444F	TCGA-D3-A8GL	SKCM	TCGA	ASSTS	DEG_SPOP_SBC_1	0.1111
p.L444F	DO50287	SKCM	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.P459L	TCGA-HF-7132	STAD	TCGA	ASSTS	DEG_SPOP_SBC_1	0.25
p.P459L	DO38214	STAD	ICGC	ASSTS	DEG_SPOP_SBC_1	0.25
p.T442I	DO230334	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229010	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229013	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229003	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229005	COCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229346	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO50981	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO51011	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T442I	DO229470	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.T447M	DO231159	LAML	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L444P	DO231075	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	0.1111
p.E466D	DO232532	PBCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.E466D	DO218861	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.0556
p.A452T	DO219878	SKCA	ICGC	ASSTS	DEG_SPOP_SBC_1	0.7139
p.L461Q	SIDM00457	Plasma Cell Myeloma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.L461Q	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.1944
p.D457N	SIDM00847	Rhabdomyosarcoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.3056
p.D457N	ACH-000169	Sarcoma	CCLE	ASSTS	DEG_SPOP_SBC_1	0.3056
p.D457N	RD	soft_tissue	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.3056
p.D443N	SIDM00975	Melanoma	GDSC	ASSTS	DEG_SPOP_SBC_1	0.0833
p.D443N	ACH-002206	Skin Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	0.0833
p.D443N	WM278	skin	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.0833
p.R448Q	BT-474	breast	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.2222
p.T453A	HT-115	large_intestine	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.7139
p.P466S	TMK-1	stomach	COSMIC	ASSTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1446:1450	ASSTS	SPOP	0.9991	More...
O75928	E3 SUMO-protein ligase PIAS2	DEG_SPOP_SBC_1	578:582	ASSTS	SPOP	0.9737	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1755:1759	ASSTS	SPOP	0.6619	More...
P10070	Zinc finger protein GLI2	DEG_SPOP_SBC_1	630:634	ASSTS	SPOP	0.9397	More...
P22736	Nuclear receptor subfamily 4 group A member 1	DEG_SPOP_SBC_1	85:89	ASSTS	SPOP	0.9434	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1352:1356	ASSTS	SPOP	0.9983	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	148:152	ASSTS	SPOP	0.9958	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	2:6	ASSTS	SPOP	0.9282	More...
Q04724	Transducin-like enhancer protein 1	DEG_SPOP_SBC_1	294:298	ASSTS	SPOP	0.9961	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	180:184	ASSTS	SPOP	0.9864	More...
Q5T5U3	Rho GTPase-activating protein 21	DEG_SPOP_SBC_1	791:795	ASSTS	SPOP	0.9947	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	520:524	ASSTS	SPOP	0.8668	More...
Q6ZUJ8	Phosphoinositide 3-kinase adapter protein 1	DEG_SPOP_SBC_1	723:727	ASSTS	SPOP	0.9991	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1125:1129	ASSTS	SPOP	0.9989	More...
Q7Z460	CLIP-associating protein 1	DEG_SPOP_SBC_1	255:259	ASSTS	SPOP	0.9466	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6830:6834	ASSTS	SPOP	0.963	More...
Q8IZR5	CKLF-like MARVEL transmembrane domain-containing protein 4	DEG_SPOP_SBC_1	14:18	ASSTS	SPOP	0.9523	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	452:456	ASSTS	SPOP	0.9768	More...
Q8N8S7	Protein enabled homolog	DEG_SPOP_SBC_1	484:488	ASSTS	SPOP	0.9828	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	676:680	ASSTS	SPOP	0.9986	More...
Q96JM7	Lethal	DEG_SPOP_SBC_1	5:9	ASSTS	SPOP	0.9955	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	98:102	ASSTS	SPOP	0.9954	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	185:189	ASSTS	SPOP	0.97	More...
Q9UH73	Transcription factor COE1	DEG_SPOP_SBC_1	525:529	ASSTS	SPOP	0.908	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	DEG_SPOP_SBC_1	1176:1180	ASSTS	SPOP	0.9955	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	158:162	ASSTS	SPOP	0.9526	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	227:231	ASSTS	SPOP	0.9062	More...
Q5RHP9	Glutamate-rich protein 3	DEG_SPOP_SBC_1	580:584	ASSTS	SPOP	0.9566	More...
Q99457	Nucleosome assembly protein 1-like 3	DEG_SPOP_SBC_1	23:27	ASSTS	SPOP	0.5181	More...
Q92628	Uncharacterized protein KIAA0232	DEG_SPOP_SBC_1	1366:1370	ASSTS	SPOP	0.9835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTS

Degron related mutations and impact score

Drug responses associated with MUC20 mutations

All proteins holding degron of ASSTS