DegronMD - P58753(TIRAP)

GO - Biological processes (BP): 3'-UTR-mediated mRNA stabilization [GO:0070935]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cell surface receptor signaling pathway [GO:0007166]; cellular response to bacterial lipopeptide [GO:0071221]; cellular response to lipoteichoic acid [GO:0071223]; defense response to Gram-positive bacterium [GO:0050830]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid cell differentiation [GO:0030099]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of innate immune response [GO:0045089]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-15 production [GO:0032738]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein-containing complex assembly [GO:0031334]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of innate immune response [GO:0045088]; regulation of interferon-beta production [GO:0032648]; regulation of stress-activated MAPK cascade [GO:0032872]; response to lipopolysaccharide [GO:0032496]; TIRAP-dependent toll-like receptor 4 signaling pathway [GO:0035665] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q49H	TCGA-19-5956	GBM	TCGA	PESTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.Q49H	DO13863	GBM	ICGC	PESTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.E41K	TCGA-BR-4370	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.591
p.E41K	DO38499	STAD	ICGC	PESTS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.591
p.P10S	TCGA-CQ-7063	HNSC	TCGA	ASSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222
p.P10S	DO14702	HNSC	ICGC	ASSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2222
p.S52P	TCGA-D1-A1NZ	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.S52P	DO41536	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.R13W	DO224768	BRCA	ICGC	ASSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.Q49R	DO234322	ESAD	ICGC	PESTS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.R13Q	DO230940	LUSC	ICGC	ASSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.1389
p.K32R	DO229227	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	40:44	Mutation substituting flanking lysine	0.2222
p.L7P	ACH-000445	Brain Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TIRAP

UniProt ID: P58753

Entrez ID: 114609

Protein name: Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TIRAP in