DegronMD

Uniprot ID: P58753

Source protein: Toll/interleukin-1 receptor domain-containing adapter protein

Source gene: TIRAP

Class: DEG_SPOP_SBC_1

Location: 40:44

E3 ligase: SPOP

DEGRON score: 0.9402

ASA_SCORE: 99.94

COIL: 0.9372

CONS_SCORE: 0.56

DSS_SCORE: 0.8455

HELIX: 0.0444

FCONS_SCORE: 1.0305

RIG_SCORE: 0.5191

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q49H	TCGA-19-5956	GBM	TCGA	PESTS	DEG_SPOP_SBC_1	0.1944
p.Q49H	DO13863	GBM	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.E41K	TCGA-BR-4370	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.591
p.E41K	DO38499	STAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.591
p.S52P	TCGA-D1-A1NZ	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	0.1111
p.S52P	DO41536	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	0.1111
p.Q49R	DO234322	ESAD	ICGC	PESTS	DEG_SPOP_SBC_1	0.1944
p.K32R	DO229227	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons