DegronMD

Uniprot ID: Q9BT25

Source protein: HAUS augmin-like complex subunit 8

Source gene: HAUS8

Class: DEG_SPOP_SBC_1

Location: 127:131

E3 ligase: SPOP

DEGRON score: 0.9807

ASA_SCORE: 90.84

COIL: 0.888

CONS_SCORE: 0.5012

DSS_SCORE: 0.6082

HELIX: 0.0958

FCONS_SCORE: 1.1722

RIG_SCORE: 0.62

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S131A	TCGA-12-3651	GBM	TCGA	PESTS	DEG_SPOP_SBC_1	0.87
p.T122A	TCGA-17-Z033	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.6389
p.P140L	TCGA-2W-A8YY	CESC	TCGA	PESTS	DEG_SPOP_SBC_1	0.0833
p.P117Q	TCGA-78-7535	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	0.0556
p.S124L	TCGA-CQ-5331	HNSC	TCGA	PESTS	DEG_SPOP_SBC_1	0.6944
p.P139L	DO223732	CESC	ICGC	PESTS	DEG_SPOP_SBC_1	0.5556
p.S130A	DO13845	GBM	ICGC	PESTS	DEG_SPOP_SBC_1	0.7588
p.S123L	DO15495	HNSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222
p.R135Q	DO231596	LINC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2222
p.S131L	ACH-001694	Head and Neck Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.8778
p.C121F	CAPAN-1	pancreas	COSMIC	PESTS	DEG_SPOP_SBC_1	0.2778
p.K122E	HSC-2	upper_aerodigestive_tract	COSMIC	PESTS	DEG_SPOP_SBC_1	0.6389
p.S141F	JHH-7	liver	COSMIC	PESTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons