DegronMD - Q8N3X1(FNBP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S472C	TCGA-3C-AALI	BRCA	TCGA	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.S472C	DO219589	BRCA	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.D478N	TCGA-55-6968	LUAD	TCGA	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.D478N	DO23759	LUAD	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.0833
p.E745K	TCGA-78-7539	LUAD	TCGA	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	755:762	Mutation rewiring degron network	0.0556
p.E745K	DO26210	LUAD	ICGC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	755:762	Mutation rewiring degron network	0.0556
p.P465A	TCGA-A2-A0CX	BRCA	TCGA	PESTS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.6392
p.P465A	DO2755	BRCA	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.6392
p.P178S	TCGA-A3-3367	KIRC	TCGA	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.P178S	DO16871	KIRC	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.P174H	TCGA-AA-3864	COAD	TCGA	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.P174H	DO8490	COAD	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1389
p.M687I	TCGA-AD-6895	COAD	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation altering degron motif	0.6507
p.M687I	DO8938	COAD	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation altering degron motif	0.6507
p.S191P	TCGA-AX-A0J0	UCEC	TCGA	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.S191P	DO41133	UCEC	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.L696R	TCGA-CG-5728	STAD	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation rewiring degron network	0.2778
p.L696R	DO38619	STAD	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation rewiring degron network	0.2778
p.E507Q	TCGA-CM-6168	COAD	TCGA	VQTTPKVE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1389
p.E507Q	DO9602	COAD	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	514:521	Mutation rewiring degron network	0.1389
p.P518S	TCGA-D3-A5GU	SKCM	TCGA	VQTTPKVE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.6752
p.P518S	DO47584	SKCM	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.6752
p.S676F	TCGA-EE-A2MJ	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1944
p.S676F	DO38099	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1944
p.F692L	TCGA-EI-6917	READ	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation altering degron motif	0.587
p.F692L	DO36881	READ	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation altering degron motif	0.587
p.V681A	TCGA-EO-A22R	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.5825
p.V681A	DO42713	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.5825
p.G754E	TCGA-KQ-A41Q	BLCA	TCGA	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	755:762	Mutation rewiring degron network	0.3056
p.G754E	DO223591	BLCA	ICGC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	755:762	Mutation rewiring degron network	0.3056
p.A182T	TCGA-NC-A5HD	LUSC	TCGA	AATST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6028
p.A182T	DO219184	LUSC	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6028
p.S467C	TCGA-Q1-A73O	CESC	TCGA	PESTS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7541
p.S467C	DO51612	CESC	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation altering degron motif	0.7541
p.P701S	TCGA-WE-AAA0	SKCM	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation rewiring degron network	0.1389
p.P701S	DO51294	SKCM	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation rewiring degron network	0.1389
p.S472F	TCGA-XF-AAN0	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.S472F	DO51941	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.S191L	DO225338	BRCA	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.P49R	DO229003	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	DO229346	LAML	ICGC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00590	Oral Cavity Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00293	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00292	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00280	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01217	Other Blood Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM00026	Other Solid Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01551	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01682	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01368	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01450	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.P49R	SIDM01433	Kidney Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222
p.S472A	DO228672	LICA	ICGC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.25
p.G679C	DO50929	LICA	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	687:694	Mutation rewiring degron network	0.1111
p.G679C	DO50929	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.2778
p.S188F	DO222653	MELA	ICGC	AATST	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.25
p.T517I	DO27875	ORCA	ICGC	VQTTPKVE	DEG_SCF_FBW7_2	514:521	Mutation altering degron motif	0.8189
p.A63T	DO229268	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.A63V	DO229089	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.T463I	SIDM01228	Melanoma	GDSC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.T463I	ACH-000931	Skin Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.T463I	ACH-001024	Skin Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.T463I	CHL-1	skin	COSMIC	PESTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.2778
p.S772N	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	TEEDTPLK	DEG_SCF_SKP2-CKS1_1	755:762	Mutation rewiring degron network	0.0556
p.Q48H	ACH-000052	Bone Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1944
p.A50T	ACH-000767	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.A65V	ACH-000940	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FNBP4

UniProt ID: Q8N3X1

Entrez ID: 23360

Protein name: Formin-binding protein 4 (Formin-binding protein 30)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FNBP4 in