DegronMD

Uniprot ID: Q8N3X1

Source protein: Formin-binding protein 4

Source gene: FNBP4

Class: DEG_SCF_FBW7_1

Location: 687:694

E3 ligase: FBXW7

DEGRON score: 0.5499

ASA_SCORE: 68.075

COIL: 0.7464

CONS_SCORE: 0.4505

DSS_SCORE: 0.3039

HELIX: 0.201

FCONS_SCORE: 1.0362

RIG_SCORE: 0.7833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M687I	TCGA-AD-6895	COAD	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	0.6507
p.M687I	DO8938	COAD	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	0.6507
p.L696R	TCGA-CG-5728	STAD	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	0.2778
p.L696R	DO38619	STAD	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	0.2778
p.F692L	TCGA-EI-6917	READ	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	0.587
p.F692L	DO36881	READ	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	0.587
p.P701S	TCGA-WE-AAA0	SKCM	TCGA	MPLTPFWT	DEG_SCF_FBW7_1	0.1389
p.P701S	DO51294	SKCM	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	0.1389
p.G679C	DO50929	LICA	ICGC	MPLTPFWT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3X1	Formin-binding protein 4	DEG_SCF_FBW7_1	687:694	MPLTPFWT	FBXW7	0.5499	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons