DegronMD

Uniprot ID: Q8N3X1

Source protein: Formin-binding protein 4

Source gene: FNBP4

Class: DEG_SPOP_SBC_1

Location: 53:57

E3 ligase: SPOP

DEGRON score: 0.704

ASA_SCORE: 67.42

COIL: 0.7126

CONS_SCORE: 0.2527

DSS_SCORE: 0.681

HELIX: 0.2216

FCONS_SCORE: 0.9712

RIG_SCORE: 0.6289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P49R	DO229003	COCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	DO229346	LAML	ICGC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00590	Oral Cavity Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00293	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00292	Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00280	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01217	Other Blood Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM00026	Other Solid Cancers	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01551	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01682	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01368	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01450	Gastric Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.P49R	SIDM01433	Kidney Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.2222
p.A63T	DO229268	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.A63V	DO229089	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	0.1667
p.Q48H	ACH-000052	Bone Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1944
p.A50T	ACH-000767	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.25
p.A65V	ACH-000940	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons