DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SPOP_SBC_1

Location: 1824:1828

E3 ligase: SPOP

DEGRON score: 0.6214

ASA_SCORE: 75.06

COIL: 0.8702

CONS_SCORE: 0.3275

DSS_SCORE: 0.2449

HELIX: 0.0404

FCONS_SCORE: 0.888

RIG_SCORE: 0.7651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1829T	TCGA-22-5471	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	0.3056
p.T1828A	TCGA-2Y-A9H0	LIHC	TCGA	AATTT	DEG_SPOP_SBC_1	0.7139
p.G1816D	TCGA-A6-3808	COAD	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.G1816D	DO8408	COAD	ICGC	AATTT	DEG_SPOP_SBC_1	0.1111
p.Q1814H	TCGA-FS-A1ZR	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	0.0556
p.F1836L	TCGA-KL-8333	KICH	TCGA	AATTT	DEG_SPOP_SBC_1	0.1111
p.F1826L	DO220341	KICH	ICGC	AATTT	DEG_SPOP_SBC_1	0.6981
p.A1819T	DO27500	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	0.1944
p.G1838C	DO52402	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	0.0556
p.T1826A	SIDM00373	Endometrial Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	0.7139
p.T1826A	ACH-000974	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.7139
p.T1826A	ACH-002026	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	0.7139
p.T1826A	ACH-002710	Sarcoma	CCLE	AATTT	DEG_SPOP_SBC_1	0.7139
p.T1826A	SNG-M	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	0.7139
p.T1816A	SNG-M	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	542:546	AATTT	SPOP	0.611	More...
O60907	F-box-like/WD repeat-containing protein TBL1X	DEG_SPOP_SBC_1	174:178	AATTT	SPOP	0.6842	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1824:1828	AATTT	SPOP	0.6214	More...
P55318	Hepatocyte nuclear factor 3-gamma	DEG_SPOP_SBC_1	226:230	AATTT	SPOP	0.9972	More...
Q5PRF9	Protein Smaug homolog 2	DEG_SPOP_SBC_1	403:407	AATTT	SPOP	0.9499	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	1143:1147	AATTT	SPOP	0.8846	More...
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	156:160	AATTT	SPOP	0.6639	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	852:856	AATTT	SPOP	0.9784	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	99:103	AATTT	SPOP	0.8339	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	172:176	AATTT	SPOP	0.8881	More...
Q96N19	Integral membrane protein GPR137	DEG_SPOP_SBC_1	349:353	AATTT	SPOP	0.882	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	69:73	AATTT	SPOP	0.9948	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2999:3003	AATTT	SPOP	0.9608	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3141:3145	AATTT	SPOP	0.995	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4398:4402	AATTT	SPOP	0.999	More...
Q9HCJ2	Leucine-rich repeat-containing protein 4C	DEG_SPOP_SBC_1	445:449	AATTT	SPOP	0.8689	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	217:221	AATTT	SPOP	0.9943	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	53:57	AATTT	SPOP	0.704	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons