DegronMD - Q8IZL2(MAML2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P799T	TCGA-A8-A09A	BRCA	TCGA	PPDY	ITCH	798:801	Mutation altering degron motif	0.7031
p.P799T	DO2955	BRCA	ICGC	PPDY	ITCH	798:801	Mutation altering degron motif	0.7031
p.L849M	TCGA-AP-A1DK	UCEC	TCGA	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2778
p.L849M	DO222842	COCA	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2778
p.L849M	DO42033	UCEC	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2778
p.S401L	TCGA-AX-A05Z	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7667
p.S401L	TCGA-BS-A0UV	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7667
p.S401L	DO40884	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7667
p.S401L	DO42793	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7667
p.H137L	TCGA-AX-A2HD	UCEC	TCGA	PPDY	ITCH	127:130	Mutation rewiring degron network	0.1389
p.H137L	DO42608	UCEC	ICGC	PPDY	ITCH	127:130	Mutation rewiring degron network	0.1389
p.V407I	TCGA-CK-6746	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.V407I	DO7938	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.P405L	TCGA-CV-A45Z	HNSC	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.P405L	DO52064	HNSC	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.S837L	TCGA-D1-A16J	UCEC	TCGA	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2222
p.S837L	DO43033	UCEC	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2222
p.T121A	TCGA-DD-A1E9	LIHC	TCGA	PPDY	ITCH	127:130	Mutation rewiring degron network	0.1667
p.T121A	DO22890	LIHC	ICGC	PPDY	ITCH	127:130	Mutation rewiring degron network	0.1667
p.N791S	TCGA-F7-A624	HNSC	TCGA	PPDY	ITCH	798:801	Mutation rewiring degron network	0.1389
p.N791S	DO44440	HNSC	ICGC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.1389
p.L848I	TCGA-IB-7651	PAAD	TCGA	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.3056
p.L848I	DO46657	PAAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.3056
p.G388S	TCGA-IN-A6RI	STAD	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.G388S	DO51736	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.D803N	TCGA-MZ-A7D7	HNSC	TCGA	PPDY	ITCH	798:801	Mutation rewiring degron network	0.2778
p.D803N	DO52093	HNSC	ICGC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.2778
p.R806K	TCGA-N6-A4VF	UCS	TCGA	PPDY	ITCH	798:801	Mutation rewiring degron network	0.1944
p.P127S	TCGA-V5-AASW	ESCA	TCGA	PPDY	ITCH	127:130	Mutation altering degron motif	0.6752
p.L848P	TCGA-VQ-A8PX	STAD	TCGA	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.3056
p.L848P	DO51778	STAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.3056
p.P403S	TCGA-WE-A8ZX	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2778
p.P403S	DO51291	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2778
p.R806I	DO222830	BTCA	ICGC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.1944
p.A118S	DO227549	COCA	ICGC	PPDY	ITCH	127:130	Mutation rewiring degron network	0.0833
p.Q789R	DO233281	GACA	ICGC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.0833
p.A95D	DO229028	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.S410R	DO229027	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.P408T	DO229008	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1389
p.A110S	DO50889	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.1389
p.D788N	DO23402	LINC	ICGC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.0556
p.P107L	DO51177	PAEN	ICGC	AATTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2222
p.P844A	DO50419	PRAD	ICGC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation altering degron motif	0.7503
p.P799S	DO229502	SKCA	ICGC	PPDY	ITCH	798:801	Mutation altering degron motif	0.6752
p.M857V	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.0556
p.M857V	SIDM01107	Melanoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.0556
p.M857V	SIDM00900	Non-Cancerous	GDSC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.0556
p.M857V	SIDM00261	Ewing's Sarcoma	GDSC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.0556
p.P389L	SIDM00179	Melanoma	GDSC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.P389L	ACH-002165	Skin Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.P389L	MZ2-MEL	skin	COSMIC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.N810I	SIDM00999	Bladder Carcinoma	GDSC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.0833
p.N810I	ACH-000973	Bladder Cancer	CCLE	PPDY	ITCH	798:801	Mutation rewiring degron network	0.0833
p.N810I	639-V	urinary tract	COSMIC	PPDY	ITCH	798:801	Mutation rewiring degron network	0.0833
p.D129N	ACH-000269	Brain Cancer	CCLE	PPDY	ITCH	127:130	Mutation altering degron motif	0.5821
p.D129N	ACH-000532	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	127:130	Mutation altering degron motif	0.5821
p.A97S	ACH-000946	Endometrial/Uterine Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.S840P	EFM-19	breast	COSMIC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.3056
p.P406T	KYSE-220	oesophagus	COSMIC	ALSTS	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.Q849R	D-263MG	central nervous system	COSMIC	ILTPNSS	DEG_SCF_FBW7_1	841:847	Mutation rewiring degron network	0.2778
p.K97N	HEC-1	endometrium	COSMIC	AATTT	DEG_SPOP_SBC_1	99:103	Mutation rewiring degron network	0.2778
p.P134H	LNCaP-Clone-FGC	prostate	COSMIC	PPDY	ITCH	127:130	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAML2

UniProt ID: Q8IZL2

Entrez ID: 84441

Protein name: Mastermind-like protein 2 (Mam-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAML2 in