DegronMD

Uniprot ID: Q8IZL2

Source protein: Mastermind-like protein 2

Source gene: MAML2

Class: DEG_SPOP_SBC_1

Location: 397:401

E3 ligase: SPOP

DEGRON score: 0.9214

ASA_SCORE: 95.62

COIL: 0.9592

CONS_SCORE: 0.6159

DSS_SCORE: 0.5764

HELIX: 0.0278

FCONS_SCORE: 1.0154

RIG_SCORE: 0.5887

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S401L	TCGA-AX-A05Z	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7667
p.S401L	TCGA-BS-A0UV	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7667
p.S401L	DO40884	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7667
p.S401L	DO42793	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7667
p.P403S	TCGA-WE-A8ZX	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.2778
p.P403S	DO51291	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.P405L	TCGA-CV-A45Z	HNSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.2222
p.P405L	DO52064	HNSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.P406T	KYSE-220	oesophagus	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.V407I	TCGA-CK-6746	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.V407I	DO7938	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1667
p.P408T	DO229008	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.P389L	SIDM00179	Melanoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.P389L	ACH-002165	Skin Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.1111
p.P389L	MZ2-MEL	skin	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.G388S	TCGA-IN-A6RI	STAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.0833
p.G388S	DO51736	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.S410R	DO229027	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...

Showing 1 to 13 of 13 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons