DegronMD - Q96F81(DISP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1168I	TCGA-AX-A2HC	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.5833
p.S1168I	DO41572	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.5833
p.S1152G	TCGA-B5-A3FA	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1944
p.S1152G	DO52402	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.1944
p.A1157T	TCGA-B5-A3FA	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation altering degron motif	0.7139
p.A1157T	DO52402	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation altering degron motif	0.7139
p.S1155F	TCGA-EB-A3Y6	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.7222
p.S1155F	TCGA-FS-A1Z3	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.7222
p.S1155F	DO37635	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.7222
p.S1155F	DO38081	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation blocking phosphorylation signal	0.7222
p.D1164G	DO233885	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.25
p.A1157D	DO232761	PBCA	ICGC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation altering degron motif	0.7793
p.S1163G	SIDM00672	Hepatocellular Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM00845	Burkitt's Lymphoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM00633	Breast Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM00654	Small Cell Lung Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM00690	Head and Neck Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM00210	Ovarian Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.S1163G	SIDM01173	Rhabdomyosarcoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.2778
p.H1156Y	SIDM00190	Melanoma	GDSC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.3056
p.H1156Y	ACH-002097	Skin Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.3056
p.H1156Y	CP66-MEL	skin	COSMIC	ALSTS	DEG_SPOP_SBC_1	1157:1161	Mutation rewiring degron network	0.3056

Kaplan plot for DISP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DISP1

UniProt ID: Q96F81

Entrez ID: 84976

Protein name: Protein dispatched homolog 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DISP1 in