DegronMD

Uniprot ID: Q96F81

Source protein: Protein dispatched homolog 1

Source gene: DISP1

Class: DEG_SPOP_SBC_1

Location: 1157:1161

E3 ligase: SPOP

DEGRON score: 0.6075

ASA_SCORE: 87.02

COIL: 0.803

CONS_SCORE: 0.2568

DSS_SCORE: 0.3884

HELIX: 0.18

FCONS_SCORE: 0.928

RIG_SCORE: 0.6399

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1168I	TCGA-AX-A2HC	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.5833
p.S1168I	DO41572	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.5833
p.S1152G	TCGA-B5-A3FA	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1944
p.S1152G	DO52402	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.A1157T	TCGA-B5-A3FA	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A1157T	DO52402	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.S1155F	TCGA-EB-A3Y6	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7222
p.S1155F	TCGA-FS-A1Z3	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7222
p.S1155F	DO37635	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7222
p.S1155F	DO38081	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7222
p.D1164G	DO233885	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.A1157D	DO232761	PBCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7793
p.S1163G	SIDM00672	Hepatocellular Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM00845	Burkitt's Lymphoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM00633	Breast Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM00654	Small Cell Lung Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM00690	Head and Neck Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM00210	Ovarian Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.S1163G	SIDM01173	Rhabdomyosarcoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.H1156Y	SIDM00190	Melanoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.H1156Y	ACH-002097	Skin Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.3056
p.H1156Y	CP66-MEL	skin	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons