DegronMD

Uniprot ID: Q96QB1

Source protein: Rho GTPase-activating protein 7

Source gene: DLC1

Class: DEG_SPOP_SBC_1

Location: 372:376

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 71.76

COIL: 0.6898

CONS_SCORE: 0.3148

DSS_SCORE: 0.6206

HELIX: 0.2914

FCONS_SCORE: 1.1353

RIG_SCORE: 0.6417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T382R	TCGA-56-8308	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.T382R	DO219140	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1667
p.D366H	TCGA-60-2695	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.D366H	DO26665	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1667
p.Q367K	TCGA-70-6722	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1944
p.Q367K	TCGA-E7-A7DV	BLCA	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1944
p.Q367K	DO48583	BLCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.Q367K	DO27755	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.L373I	TCGA-AX-A2HD	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.6063
p.L373I	DO42608	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.6063
p.A372T	TCGA-EO-A3AV	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A372T	DO52412	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.D368N	DO228246	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.E362K	DO1073	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0556
p.T368M	DO8447	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.D368E	DO222588	COCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.S374R	DO218243	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.8538
p.Y364S	DO233760	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.P383Q	DO228952	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.P378S	DO51761	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.P383S	SIDM01175	Other Sarcomas	GDSC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.P383S	ACH-002309	Sarcoma	CCLE	ALSTS	DEG_SPOP_SBC_1	0.1389
p.P383S	SW684	soft_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.N380S	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.N380S	D-423MG	central_nervous_system	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.D377Y	LS-411N	large_intestine	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.R368W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.N380K	DU-145	prostate	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSTS

Degron related mutations and impact score

Drug responses associated with DLC1 mutations

All proteins holding degron of ALSTS