DegronMD - Q8IZM8(ZNF654)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V536M	TCGA-AA-A02R	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.7208
p.V536M	ACH-000786	Lymphoma	CCLE	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.7208
p.K538T	TCGA-E6-A1LX	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.K538T	DO41020	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.Y537S	DO223019	ESCA	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.T524A	DO233634	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1111
p.V527L	DO229036	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation substituting flanking lysine	0.3056
p.R545K	DO34728	PACA	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.0833
p.D525N	DO35106	PACA	ICGC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1389
p.K527T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation substituting flanking lysine	0.3056
p.K527T	KCL-22	haematopoietic and lymphoid tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation substituting flanking lysine	0.3056
p.S1062I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	1052:1055	Mutation rewiring degron network	0.1389
p.S1062I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	1052:1055	Mutation rewiring degron network	0.1389
p.K1065I	SIDM00258	Neuroblastoma	GDSC	PPSY	ITCH	1052:1055	Mutation substituting flanking lysine	0.1667
p.K1065I	NB12	autonomic ganglia	COSMIC	PPSY	ITCH	1052:1055	Mutation substituting flanking lysine	0.1667
p.T922I	SIDM00046	Non-Small Cell Lung Carcinoma	GDSC	PVSTS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1389
p.T922I	H3255	lung	COSMIC	PVSTS	DEG_SPOP_SBC_1	911:915	Mutation rewiring degron network	0.1389
p.S540P	ACH-000786	Lymphoma	CCLE	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2222
p.S540P	ACH-000992	Head and Neck Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2222
p.S540P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2222
p.A529G	ACH-000937	Leukemia	CCLE	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.25
p.A529G	PF-382	haematopoietic and lymphoid tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.25

Kaplan plot for ZNF654 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF654

UniProt ID: Q8IZM8

Entrez ID:

Protein name: Zinc finger protein 654 (Melanoma-associated antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF654 in