DegronMD

Uniprot ID: Q8IZM8

Source protein: Zinc finger protein 654

Source gene: ZNF654

Class: DEG_SPOP_SBC_1

Location: 532:536

E3 ligase: SPOP

DEGRON score: 0.8723

ASA_SCORE: 86.74

COIL: 0.8106

CONS_SCORE: 0.5111

DSS_SCORE: 0.5166

HELIX: 0.1366

FCONS_SCORE: 0.9512

RIG_SCORE: 0.7249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V536M	TCGA-AA-A02R	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7208
p.V536M	ACH-000786	Lymphoma	CCLE	ALSTS	DEG_SPOP_SBC_1	0.7208
p.K538T	TCGA-E6-A1LX	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.2778
p.K538T	DO41020	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.Y537S	DO223019	ESCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.T524A	DO233634	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.V527L	DO229036	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.R545K	DO34728	PACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.D525N	DO35106	PACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.K527T	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.K527T	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.S540P	ACH-000786	Lymphoma	CCLE	ALSTS	DEG_SPOP_SBC_1	0.2222
p.S540P	ACH-000992	Head and Neck Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.2222
p.S540P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.A529G	ACH-000937	Leukemia	CCLE	ALSTS	DEG_SPOP_SBC_1	0.25
p.A529G	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons