DegronMD

Uniprot ID: Q8NDW4

Source protein: Zinc finger protein 248

Source gene: ZNF248

Class: DEG_SPOP_SBC_1

Location: 575:579

E3 ligase: SPOP

DEGRON score: 0.9962

ASA_SCORE: 70.24

COIL: 0.8784

CONS_SCORE: 0.819

DSS_SCORE: 0.8342

HELIX: 0.0148

FCONS_SCORE: 0.848

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R568I	TCGA-AA-3977	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1389
p.R568I	TCGA-AG-A002	READ	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1389
p.R568I	DO8730	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.A575T	TCGA-AP-A0LM	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A575T	DO43306	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.R572G	TCGA-CV-6951	HNSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.25
p.R572G	DO15278	HNSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.Q567H	DO225215	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.Q567H	DO227836	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1111
p.T571I	DO233238	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.H566N	DO229037	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.S579F	DO222837	MELA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons