DegronMD - Q14190(SIM2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S361P	TCGA-4R-AA8I	LIHC	TCGA	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.6752
p.S361P	DO49657	LIHC	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.6752
p.S355F	TCGA-56-1622	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2222
p.S355F	DO26461	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2222
p.L421M	TCGA-A5-A0G1	UCEC	TCGA	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.5999
p.L421M	DO42472	UCEC	ICGC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation altering degron motif	0.5999
p.K368N	TCGA-FU-A3HZ	CESC	TCGA	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation substituting flanking lysine	0.3056
p.K368N	DO6308	CESC	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation substituting flanking lysine	0.3056
p.L369S	TCGA-G7-A8LD	KIRP	TCGA	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1667
p.L369S	DO49761	KIRP	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.1667
p.S503Y	TCGA-IR-A3LA	CESC	TCGA	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.S503Y	DO44377	CESC	ICGC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.3056
p.P512Q	TCGA-L5-A4OI	ESCA	TCGA	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.P512L	DO6392	CLLE	ICGC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.P512L	SIDM01186	Breast Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.P512L	ACH-000554	Breast Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.P512L	UACC-893	breast	COSMIC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.T433M	DO230326	COCA	ICGC	LLYTPSYS	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7423
p.T433M	DO224616	COCA	ICGC	LLYTPSYS	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.7423
p.L360F	DO229015	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.587
p.A350S	DO228343	MALY	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0833
p.R357K	DO51962	PRAD	ICGC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2778
p.A359T	SIDM02050	Colorectal Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.7139
p.A417P	SIDM02050	Colorectal Carcinoma	GDSC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.2222
p.P418L	SIDM00608	Plasma Cell Myeloma	GDSC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.25
p.P418L	ACH-000714	Myeloma	CCLE	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.25
p.P418L	KMS-11	haematopoietic and lymphoid tissue	COSMIC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.25
p.P434S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LLYTPSYS	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6752
p.P434S	ACH-000924	Lung Cancer	CCLE	LLYTPSYS	DEG_SCF_FBW7_1	430:437	Mutation altering degron motif	0.6752
p.H492L	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.H492L	ACH-000442	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.H492L	RERF-LC-Sq1	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1667
p.P412S	SIDM00983	Bladder Carcinoma	GDSC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0833
p.P412S	ACH-000896	Bladder Cancer	CCLE	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0833
p.P412S	647-V	urinary tract	COSMIC	LQPHSE	LIG_APCC_ABBA_1	421:426	Mutation rewiring degron network	0.0833
p.Q490R	ACH-000937	Leukemia	CCLE	VPSSS	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111

Kaplan plot for SIM2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIM2

UniProt ID: Q14190

Entrez ID: 6493

Protein name: Single-minded homolog 2 (Class E basic helix-loop-helix protein 15) (bHLHe15)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SIM2 in