DegronMD

Uniprot ID: Q14190

Source protein: Single-minded homolog 2

Source gene: SIM2

Class: DEG_SCF_FBW7_1

Location: 430:437

E3 ligase: FBXW7

DEGRON score: 0.7723

ASA_SCORE: 77.575

COIL: 0.8415

CONS_SCORE: 0.3584

DSS_SCORE: 0.2411

HELIX: 0.0968

FCONS_SCORE: 1.0206

RIG_SCORE: 0.711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T433M	DO230326	COCA	ICGC	LLYTPSYS	DEG_SCF_FBW7_1	0.7423
p.T433M	DO224616	COCA	ICGC	LLYTPSYS	DEG_SCF_FBW7_1	0.7423
p.P434S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LLYTPSYS	DEG_SCF_FBW7_1	0.6752
p.P434S	ACH-000924	Lung Cancer	CCLE	LLYTPSYS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14190	Single-minded homolog 2	DEG_SCF_FBW7_1	430:437	LLYTPSYS	FBXW7	0.7723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons