DegronMD

Uniprot ID: Q14190

Source protein: Single-minded homolog 2

Source gene: SIM2

Class: LIG_APCC_ABBA_1

Location: 421:426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.505

ASA_SCORE: 99.3833

COIL: 0.9267

CONS_SCORE: 0.3199

DSS_SCORE: 0.523

HELIX: 0.0478

FCONS_SCORE: 0.8922

RIG_SCORE: 0.6284

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L421M	TCGA-A5-A0G1	UCEC	TCGA	LQPHSE	LIG_APCC_ABBA_1	0.5999
p.L421M	DO42472	UCEC	ICGC	LQPHSE	LIG_APCC_ABBA_1	0.5999
p.A417P	SIDM02050	Colorectal Carcinoma	GDSC	LQPHSE	LIG_APCC_ABBA_1	0.2222
p.P418L	SIDM00608	Plasma Cell Myeloma	GDSC	LQPHSE	LIG_APCC_ABBA_1	0.25
p.P418L	ACH-000714	Myeloma	CCLE	LQPHSE	LIG_APCC_ABBA_1	0.25
p.P418L	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	LQPHSE	LIG_APCC_ABBA_1	0.25
p.P412S	SIDM00983	Bladder Carcinoma	GDSC	LQPHSE	LIG_APCC_ABBA_1	0.0833
p.P412S	ACH-000896	Bladder Cancer	CCLE	LQPHSE	LIG_APCC_ABBA_1	0.0833
p.P412S	647-V	urinary_tract	COSMIC	LQPHSE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14190	Single-minded homolog 2	LIG_APCC_ABBA_1	421:426	LQPHSE	APC,CDC20,FZR1	0.505	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons