DegronMD

Uniprot ID: Q14190

Source protein: Single-minded homolog 2

Source gene: SIM2

Class: DEG_SPOP_SBC_1

Location: 359:363

E3 ligase: SPOP

DEGRON score: 0.9978

ASA_SCORE: 76.5

COIL: 0.7796

CONS_SCORE: 0.3986

DSS_SCORE: 0.5004

HELIX: 0.2

FCONS_SCORE: 1.2441

RIG_SCORE: 0.7136

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S361P	TCGA-4R-AA8I	LIHC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.6752
p.S361P	DO49657	LIHC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.6752
p.S355F	TCGA-56-1622	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.2222
p.S355F	DO26461	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.K368N	TCGA-FU-A3HZ	CESC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.3056
p.K368N	DO6308	CESC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.L369S	TCGA-G7-A8LD	KIRP	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.L369S	DO49761	KIRP	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1667
p.L360F	DO229015	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.587
p.A350S	DO228343	MALY	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.R357K	DO51962	PRAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.A359T	SIDM02050	Colorectal Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons