DegronMD - Q92558(WASF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T345N	TCGA-17-Z062	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.M344V	TCGA-DU-6392	LGG	TCGA	ALSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.M344V	DO22237	LGG	ICGC	ALSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.P325L	TCGA-EE-A29W	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.P325L	DO47658	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.0833
p.G144C	TCGA-F1-6177	STAD	TCGA	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.2778
p.G144C	DO38727	STAD	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.2778
p.L137F	TCGA-FS-A1ZF	SKCM	TCGA	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.587
p.L137F	DO38039	SKCM	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.587
p.Y140N	DO222729	COCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.7059
p.Y140C	SIDM00193	Colorectal Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.7087
p.Y140C	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.7087
p.Y140C	SNU-81	large intestine	COSMIC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation altering degron motif	0.7087
p.K145E	SIDM01045	Endometrial Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation substituting flanking lysine	0.3611
p.K145E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation substituting flanking lysine	0.3611
p.K145E	EN	endometrium	COSMIC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation substituting flanking lysine	0.3611
p.Y151H	SIDM01608	Endometrial Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0833
p.Y151H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0833

Kaplan plot for WASF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WASF1

UniProt ID: Q92558

Entrez ID: 8936

Protein name: Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WASF1 in