DegronMD

Uniprot ID: Q92558

Source protein: Wiskott-Aldrich syndrome protein family member 1

Source gene: WASF1

Class: LIG_APCC_ABBA_1

Location: 137:142

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.992

ASA_SCORE: 56.3667

COIL: 0.7608

CONS_SCORE: 0.7337

DSS_SCORE: 0.4562

HELIX: 0.0338

FCONS_SCORE: 0.9895

RIG_SCORE: 0.8056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G144C	TCGA-F1-6177	STAD	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.2778
p.G144C	DO38727	STAD	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.2778
p.L137F	TCGA-FS-A1ZF	SKCM	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.587
p.L137F	DO38039	SKCM	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.587
p.Y140N	DO222729	COCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.7059
p.Y140C	SIDM00193	Colorectal Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.7087
p.Y140C	ACH-000991	Colon/Colorectal Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	0.7087
p.Y140C	SNU-81	large_intestine	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.7087
p.K145E	SIDM01045	Endometrial Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.3611
p.K145E	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	0.3611
p.K145E	EN	endometrium	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.3611
p.Y151H	SIDM01608	Endometrial Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.0833
p.Y151H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92558	Wiskott-Aldrich syndrome protein family member 1	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.992	More...
Q9UPY6	Wiskott-Aldrich syndrome protein family member 3	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.9911	More...
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2	LIG_APCC_ABBA_1	136:141	LTPYRD	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons