DegronMD

Uniprot ID: Q9Y6W5

Source protein: Wiskott-Aldrich syndrome protein family member 2

Source gene: WASF2

Class: LIG_APCC_ABBA_1

Location: 136:141

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 64.0833

COIL: 0.8023

CONS_SCORE: 0.709

DSS_SCORE: 0.4763

HELIX: 0.0858

FCONS_SCORE: 0.9753

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P131S	TCGA-A5-A0G2	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.1944
p.P131S	DO41235	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.1944
p.L147F	TCGA-B5-A11E	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.1667
p.L147F	DO41644	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.1667
p.P130S	TCGA-BT-A20J	BLCA	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.1667
p.P130S	DO457	BLCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.1667
p.L133I	TCGA-CQ-5333	HNSC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.25
p.L133I	DO14218	HNSC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.Y150C	TCGA-D1-A103	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.5278
p.Y150C	DO42312	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.5278
p.L136V	TCGA-DR-A0ZM	CESC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.5654
p.L136V	DO6254	CESC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.5654
p.T151K	DO228952	LICA	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.0556
p.K148R	SIDM00238	Ovarian Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.K148R	SIDM00368	Small Cell Lung Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.K148R	SIDM01570	Ovarian Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.K148R	OVK-18	ovary	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.K148R	SBC-5	lung	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92558	Wiskott-Aldrich syndrome protein family member 1	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.992	More...
Q9UPY6	Wiskott-Aldrich syndrome protein family member 3	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.9911	More...
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2	LIG_APCC_ABBA_1	136:141	LTPYRD	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons