DegronMD - Q9Y6W5(WASF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P131S	TCGA-A5-A0G2	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.P131S	DO41235	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1944
p.L147F	TCGA-B5-A11E	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1667
p.L147F	DO41644	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1667
p.P130S	TCGA-BT-A20J	BLCA	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1667
p.P130S	DO457	BLCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.1667
p.G345W	TCGA-CK-4951	COAD	TCGA	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.G345W	DO10582	COAD	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.L133I	TCGA-CQ-5333	HNSC	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.25
p.L133I	DO14218	HNSC	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.25
p.Y150C	TCGA-D1-A103	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation blocking phosphorylation signal	0.5278
p.Y150C	DO42312	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation blocking phosphorylation signal	0.5278
p.A362S	TCGA-D9-A6EC	SKCM	TCGA	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2778
p.A362S	DO50291	SKCM	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.2778
p.L136V	TCGA-DR-A0ZM	CESC	TCGA	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation altering degron motif	0.5654
p.L136V	DO6254	CESC	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation altering degron motif	0.5654
p.S351L	TCGA-FD-A3SQ	BLCA	TCGA	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.6667
p.S351L	DO462	BLCA	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.6667
p.G345E	TCGA-S9-A6UA	LGG	TCGA	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.G345E	DO50193	LGG	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.0556
p.D360N	TCGA-ZF-A9RC	BLCA	TCGA	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6932
p.D360N	DO219068	BLCA	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6932
p.T151K	DO228952	LICA	ICGC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation rewiring degron network	0.0556
p.P348L	DO231512	LINC	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation rewiring degron network	0.1389
p.H358Q	DO35126	PACA	ICGC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.7582
p.T346M	SIDM01171	Glioblastoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.5278
p.T346M	SIDM00795	Melanoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.5278
p.T346M	SIDM00875	Breast Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.5278
p.T346M	SIDM00807	Bladder Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.5278
p.T346M	SIDM01752	Pancreatic Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation blocking phosphorylation signal	0.5278
p.P359L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6471
p.P359L	ACH-002256	Leukemia	CCLE	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6471
p.P359L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	FPPHPD	LIG_APCC_ABBA_1	355:360	Mutation altering degron motif	0.6471
p.K148R	SIDM00238	Ovarian Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation substituting flanking lysine	0.25
p.K148R	SIDM00368	Small Cell Lung Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation substituting flanking lysine	0.25
p.K148R	SIDM01570	Ovarian Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation substituting flanking lysine	0.25
p.K148R	OVK-18	ovary	COSMIC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation substituting flanking lysine	0.25
p.K148R	SBC-5	lung	COSMIC	LTPYRD	LIG_APCC_ABBA_1	136:141	Mutation substituting flanking lysine	0.25

Kaplan plot for WASF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WASF2

UniProt ID: Q9Y6W5

Entrez ID: 10163

Protein name: Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WASF2 in