DegronMD

Uniprot ID: Q9Y6W5

Source protein: Wiskott-Aldrich syndrome protein family member 2

Source gene: WASF2

Class: LIG_APCC_ABBA_1

Location: 355:360

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9455

ASA_SCORE: 93.1833

COIL: 0.9382

CONS_SCORE: 0.4424

DSS_SCORE: 0.7238

HELIX: 0.0473

FCONS_SCORE: 0.8168

RIG_SCORE: 0.4741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G345W	TCGA-CK-4951	COAD	TCGA	FPPHPD	LIG_APCC_ABBA_1	0.0556
p.G345W	DO10582	COAD	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.0556
p.A362S	TCGA-D9-A6EC	SKCM	TCGA	FPPHPD	LIG_APCC_ABBA_1	0.2778
p.A362S	DO50291	SKCM	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.2778
p.S351L	TCGA-FD-A3SQ	BLCA	TCGA	FPPHPD	LIG_APCC_ABBA_1	0.6667
p.S351L	DO462	BLCA	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.6667
p.G345E	TCGA-S9-A6UA	LGG	TCGA	FPPHPD	LIG_APCC_ABBA_1	0.0556
p.G345E	DO50193	LGG	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.0556
p.D360N	TCGA-ZF-A9RC	BLCA	TCGA	FPPHPD	LIG_APCC_ABBA_1	0.6932
p.D360N	DO219068	BLCA	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.6932
p.P348L	DO231512	LINC	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.1389
p.H358Q	DO35126	PACA	ICGC	FPPHPD	LIG_APCC_ABBA_1	0.7582
p.T346M	SIDM01171	Glioblastoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.5278
p.T346M	SIDM00795	Melanoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.5278
p.T346M	SIDM00875	Breast Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.5278
p.T346M	SIDM00807	Bladder Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.5278
p.T346M	SIDM01752	Pancreatic Carcinoma	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.5278
p.P359L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FPPHPD	LIG_APCC_ABBA_1	0.6471
p.P359L	ACH-002256	Leukemia	CCLE	FPPHPD	LIG_APCC_ABBA_1	0.6471
p.P359L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FPPHPD	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2	LIG_APCC_ABBA_1	355:360	FPPHPD	APC,CDC20,FZR1	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons