DegronMD

Uniprot ID: Q9UPY6

Source protein: Wiskott-Aldrich syndrome protein family member 3

Source gene: WASF3

Class: LIG_APCC_ABBA_1

Location: 137:142

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9911

ASA_SCORE: 79

COIL: 0.8257

CONS_SCORE: 0.7428

DSS_SCORE: 0.4798

HELIX: 0.1015

FCONS_SCORE: 0.9689

RIG_SCORE: 0.7929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D143G	TCGA-DI-A0WH	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.3056
p.D143G	DO43843	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.3056
p.F150L	TCGA-EO-A3B0	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.1111
p.F150L	DO219773	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.1111
p.Q127H	TCGA-T2-A6X2	HNSC	TCGA	LTPYRD	LIG_APCC_ABBA_1	0.0556
p.Q127H	DO219071	HNSC	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.0556
p.Y151C	DO48411	BLCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.5278
p.K130T	DO233703	GACA	ICGC	LTPYRD	LIG_APCC_ABBA_1	0.25
p.P133T	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.2222
p.P133T	SIDM01749	Osteosarcoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.2222
p.P133T	NCI-H2444	lung	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.2222
p.S128G	SIDM00282	Colorectal Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	0.0833
p.S128G	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	0.0833
p.S128G	CW-2	large_intestine	COSMIC	LTPYRD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92558	Wiskott-Aldrich syndrome protein family member 1	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.992	More...
Q9UPY6	Wiskott-Aldrich syndrome protein family member 3	LIG_APCC_ABBA_1	137:142	LTPYRD	APC,CDC20,FZR1	0.9911	More...
Q9Y6W5	Wiskott-Aldrich syndrome protein family member 2	LIG_APCC_ABBA_1	136:141	LTPYRD	APC,CDC20,FZR1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons