DegronMD - Q9UPY6(WASF3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N255S	TCGA-05-4390	LUAD	TCGA	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.5958
p.N255S	DO23562	LUAD	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.5958
p.Q261K	TCGA-CK-4950	COAD	TCGA	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.2222
p.Q261K	DO8506	COAD	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.2222
p.P254S	TCGA-DD-A39V	LIHC	TCGA	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752
p.P254S	DO44990	LIHC	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752
p.D143G	TCGA-DI-A0WH	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.3056
p.D143G	DO43843	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.3056
p.H256Q	TCGA-EE-A2GO	SKCM	TCGA	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.647
p.H256Q	DO37823	SKCM	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.647
p.T246M	TCGA-EO-A3AZ	UCEC	TCGA	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation blocking phosphorylation signal	0.6389
p.T246M	DO50078	UCEC	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation blocking phosphorylation signal	0.6389
p.F150L	TCGA-EO-A3B0	UCEC	TCGA	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.1111
p.F150L	DO219773	UCEC	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.1111
p.Q127H	TCGA-T2-A6X2	HNSC	TCGA	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0556
p.Q127H	DO219071	HNSC	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0556
p.Y151C	DO48411	BLCA	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation blocking phosphorylation signal	0.5278
p.K130T	DO233703	GACA	ICGC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation substituting flanking lysine	0.25
p.V245F	DO229045	LICA	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	DO23208	LINC	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	DO49182	PACA	ICGC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	SIDM00260	Gastric Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	SIDM00248	Gastric Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	ACH-000758	Gastric Cancer	CCLE	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.V245I	ACH-001638	Lymphoma	CCLE	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1667
p.T264I	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1389
p.T264I	ACH-002272	Lymphoma	CCLE	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1389
p.T264I	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.1389
p.P133T	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.2222
p.P133T	SIDM01749	Osteosarcoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.2222
p.P133T	NCI-H2444	lung	COSMIC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.2222
p.S128G	SIDM00282	Colorectal Carcinoma	GDSC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0833
p.S128G	ACH-000998	Colon/Colorectal Cancer	CCLE	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0833
p.S128G	CW-2	large intestine	COSMIC	LTPYRD	LIG_APCC_ABBA_1	137:142	Mutation rewiring degron network	0.0833
p.P251L	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6471
p.S257F	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.7982
p.S257F	ACH-000916	Lung Cancer	CCLE	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.7982
p.S257F	NCI-H1573	lung	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.7982
p.S257P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752
p.S257P	ACH-001127	Leukemia	CCLE	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752
p.S257P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752
p.T261I	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation rewiring degron network	0.2222
p.S254F	NCI-H1573	lung	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.7982
p.S254P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	251:257	Mutation altering degron motif	0.6752

Kaplan plot for WASF3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WASF3

UniProt ID: Q9UPY6

Entrez ID: 10810

Protein name: Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for WASF3 in