DegronMD

Uniprot ID: Q9UPY6

Source protein: Wiskott-Aldrich syndrome protein family member 3

Source gene: WASF3

Class: DEG_SCF_FBW7_1

Location: 251:257

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 83.5714

COIL: 0.9601

CONS_SCORE: 0.5431

DSS_SCORE: 0.6382

HELIX: 0.0179

FCONS_SCORE: 1.1463

RIG_SCORE: 0.5941

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N255S	TCGA-05-4390	LUAD	TCGA	PATPNHS	DEG_SCF_FBW7_1	0.5958
p.N255S	DO23562	LUAD	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.5958
p.Q261K	TCGA-CK-4950	COAD	TCGA	PATPNHS	DEG_SCF_FBW7_1	0.2222
p.Q261K	DO8506	COAD	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.2222
p.P254S	TCGA-DD-A39V	LIHC	TCGA	PATPNHS	DEG_SCF_FBW7_1	0.6752
p.P254S	DO44990	LIHC	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.6752
p.H256Q	TCGA-EE-A2GO	SKCM	TCGA	PATPNHS	DEG_SCF_FBW7_1	0.647
p.H256Q	DO37823	SKCM	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.647
p.T246M	TCGA-EO-A3AZ	UCEC	TCGA	PATPNHS	DEG_SCF_FBW7_1	0.6389
p.T246M	DO50078	UCEC	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.6389
p.V245F	DO229045	LICA	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	DO23208	LINC	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	DO49182	PACA	ICGC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	SIDM00260	Gastric Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	SIDM00248	Gastric Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	ACH-000758	Gastric Cancer	CCLE	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.V245I	ACH-001638	Lymphoma	CCLE	PATPNHS	DEG_SCF_FBW7_1	0.1667
p.T264I	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.1389
p.T264I	ACH-002272	Lymphoma	CCLE	PATPNHS	DEG_SCF_FBW7_1	0.1389
p.T264I	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.1389
p.P251L	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.6471
p.S257F	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.7982
p.S257F	ACH-000916	Lung Cancer	CCLE	PATPNHS	DEG_SCF_FBW7_1	0.7982
p.S257F	NCI-H1573	lung	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.7982
p.S257P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PATPNHS	DEG_SCF_FBW7_1	0.6752
p.S257P	ACH-001127	Leukemia	CCLE	PATPNHS	DEG_SCF_FBW7_1	0.6752
p.S257P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.6752
p.T261I	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.2222
p.S254F	NCI-H1573	lung	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.7982
p.S254P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PATPNHS	DEG_SCF_FBW7_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATPNHS

Degron related mutations and impact score

Drug responses associated with WASF3 mutations

All proteins holding degron of PATPNHS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPY6	Wiskott-Aldrich syndrome protein family member 3	DEG_SCF_FBW7_1	251:257	PATPNHS	FBXW7	0.9979	More...