DegronMD

Uniprot ID: Q92558

Source protein: Wiskott-Aldrich syndrome protein family member 1

Source gene: WASF1

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.8439

ASA_SCORE: 74.94

COIL: 0.8328

CONS_SCORE: 0.5275

DSS_SCORE: 0.7333

HELIX: 0.1486

FCONS_SCORE: 0.9212

RIG_SCORE: 0.5795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T345N	TCGA-17-Z062	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1389
p.M344V	TCGA-DU-6392	LGG	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.M344V	DO22237	LGG	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1667
p.P325L	TCGA-EE-A29W	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.0833
p.P325L	DO47658	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons