DegronMD - Q99593(TBX5)

GO - Biological processes (BP): atrial septum morphogenesis [GO:0060413]; atrioventricular bundle cell differentiation [GO:0003167]; atrioventricular node cell development [GO:0060928]; atrioventricular node cell fate commitment [GO:0060929]; atrioventricular valve morphogenesis [GO:0003181]; bundle of His cell to Purkinje myocyte communication by electrical coupling [GO:0086054]; bundle of His development [GO:0003166]; cardiac left ventricle formation [GO:0003218]; cell-cell signaling [GO:0007267]; cell-cell signaling involved in cardiac conduction [GO:0086019]; cell fate specification [GO:0001708]; cell migration involved in coronary vasculogenesis [GO:0060980]; embryonic forelimb morphogenesis [GO:0035115]; embryonic limb morphogenesis [GO:0030326]; endocardial cushion development [GO:0003197]; forelimb morphogenesis [GO:0035136]; heart development [GO:0007507]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell migration [GO:0030336]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; pattern specification process [GO:0007389]; pericardium development [GO:0060039]; positive regulation of cardiac conduction [GO:1903781]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of gap junction assembly [GO:1903598]; positive regulation of secondary heart field cardioblast proliferation [GO:0072513]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of transcription by RNA polymerase II [GO:0006357]; sinoatrial node development [GO:0003163]; ventricular septum development [GO:0003281] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N270K	TCGA-34-2604	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0556
p.N270K	DO26433	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0556
p.N286I	TCGA-44-2655	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.N286I	DO23557	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.2778
p.A280T	TCGA-44-2656	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7139
p.A280T	DO26052	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7139
p.Q290R	TCGA-4V-A9QU	THYM	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1667
p.C293W	TCGA-B5-A1N2	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0833
p.C293W	DO41602	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.0833
p.L287S	TCGA-BR-4370	STAD	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.L287S	DO38499	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.E277K	TCGA-CA-6718	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.E277K	DO7801	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.E277K	DO220896	MELA	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.L281F	TCGA-EE-A3AE	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.587
p.L281F	DO37802	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.587
p.P273H	TCGA-EO-A22U	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1389
p.P273H	DO43755	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1389
p.R279Q	TCGA-EY-A1G8	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.R279Q	DO43578	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.R279Q	SIDM00879	Breast Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.S284L	TCGA-FR-A726	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7667
p.S284L	DO48665	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7667
p.L287F	DO48276	ESCA	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.25
p.S285Y	DO229008	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.3056
p.S289F	DO229462	SKCA	ICGC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1944
p.T283I	SIDM00373	Endometrial Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7078
p.T283I	ACH-000974	Endometrial/Uterine Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7078
p.T283I	ACH-002026	Endometrial/Uterine Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7078
p.T283I	SNG-M	endometrium	COSMIC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation altering degron motif	0.7078
p.Y292C	NCI-H526	lung	COSMIC	ALSTS	DEG_SPOP_SBC_1	280:284	Mutation rewiring degron network	0.1111

Kaplan plot for TBX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX5

UniProt ID: Q99593

Entrez ID: 6910

Protein name: T-box transcription factor TBX5 (T-box protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX5 in