DegronMD

Uniprot ID: Q99593

Source protein: T-box transcription factor TBX5

Source gene: TBX5

Class: DEG_SPOP_SBC_1

Location: 280:284

E3 ligase: SPOP

DEGRON score: 0.7853

ASA_SCORE: 71.54

COIL: 0.8498

CONS_SCORE: 0.4678

DSS_SCORE: 0.5416

HELIX: 0.0966

FCONS_SCORE: 0.9586

RIG_SCORE: 0.6349

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N270K	TCGA-34-2604	LUSC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.0556
p.N270K	DO26433	LUSC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0556
p.N286I	TCGA-44-2655	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.2778
p.N286I	DO23557	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2778
p.A280T	TCGA-44-2656	LUAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7139
p.A280T	DO26052	LUAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7139
p.Q290R	TCGA-4V-A9QU	THYM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1667
p.C293W	TCGA-B5-A1N2	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.0833
p.C293W	DO41602	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.L287S	TCGA-BR-4370	STAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.25
p.L287S	DO38499	STAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.E277K	TCGA-CA-6718	COAD	TCGA	ALSTS	DEG_SPOP_SBC_1	0.25
p.E277K	DO7801	COAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.E277K	DO220896	MELA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.L281F	TCGA-EE-A3AE	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.587
p.L281F	DO37802	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.587
p.P273H	TCGA-EO-A22U	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.1389
p.P273H	DO43755	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1389
p.R279Q	TCGA-EY-A1G8	UCEC	TCGA	ALSTS	DEG_SPOP_SBC_1	0.3056
p.R279Q	DO43578	UCEC	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.R279Q	SIDM00879	Breast Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.S284L	TCGA-FR-A726	SKCM	TCGA	ALSTS	DEG_SPOP_SBC_1	0.7667
p.S284L	DO48665	SKCM	ICGC	ALSTS	DEG_SPOP_SBC_1	0.7667
p.L287F	DO48276	ESCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.25
p.S285Y	DO229008	LICA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.3056
p.S289F	DO229462	SKCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.1944
p.T283I	SIDM00373	Endometrial Carcinoma	GDSC	ALSTS	DEG_SPOP_SBC_1	0.7078
p.T283I	ACH-000974	Endometrial/Uterine Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.7078
p.T283I	ACH-002026	Endometrial/Uterine Cancer	CCLE	ALSTS	DEG_SPOP_SBC_1	0.7078
p.T283I	SNG-M	endometrium	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.7078
p.Y292C	NCI-H526	lung	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSTS

Degron related mutations and impact score

Drug responses associated with TBX5 mutations

All proteins holding degron of ALSTS