DegronMD

Uniprot ID: P04198

Source protein: N-myc proto-oncogene protein

Source gene: MYCN

Class: DEG_SPOP_SBC_1

Location: 251:255

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 73.88

COIL: 0.861

CONS_SCORE: 0.3576

DSS_SCORE: 0.8009

HELIX: 0.0968

FCONS_SCORE: 1.0336

RIG_SCORE: 0.5591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T259N	DO228262	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.2222
p.R242H	DO233207	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.R242L	DO50425	PRAD	ICGC	ALSTS	DEG_SPOP_SBC_1	0.0833
p.R251Q	SNU-175	large_intestine	COSMIC	ALSTS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_SPOP_SBC_1	1049:1053	ALSTS	SPOP	0.9657	More...
P04198	N-myc proto-oncogene protein	DEG_SPOP_SBC_1	251:255	ALSTS	SPOP	0.9983	More...
P85298	Rho GTPase-activating protein 8	DEG_SPOP_SBC_1	7:11	ALSTS	SPOP	0.6295	More...
Q14190	Single-minded homolog 2	DEG_SPOP_SBC_1	359:363	ALSTS	SPOP	0.9978	More...
Q8IZL2	Mastermind-like protein 2	DEG_SPOP_SBC_1	397:401	ALSTS	SPOP	0.9214	More...
Q92558	Wiskott-Aldrich syndrome protein family member 1	DEG_SPOP_SBC_1	334:338	ALSTS	SPOP	0.8439	More...
Q96F81	Protein dispatched homolog 1	DEG_SPOP_SBC_1	1157:1161	ALSTS	SPOP	0.6075	More...
Q96QB1	Rho GTPase-activating protein 7	DEG_SPOP_SBC_1	372:376	ALSTS	SPOP	0.9989	More...
Q99593	T-box transcription factor TBX5	DEG_SPOP_SBC_1	280:284	ALSTS	SPOP	0.7853	More...
Q9H0U6	39S ribosomal protein L18, mitochondrial	DEG_SPOP_SBC_1	23:27	ALSTS	SPOP	0.8755	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	89:93	ALSTS	SPOP	0.8851	More...
Q8IZM8	Zinc finger protein 654	DEG_SPOP_SBC_1	532:536	ALSTS	SPOP	0.8723	More...
Q8NDW4	Zinc finger protein 248	DEG_SPOP_SBC_1	575:579	ALSTS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons