DegronMD - P04198(MYCN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P44H	TCGA-13-0888	OV	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7694
p.P44H	DO30420	OV	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7694
p.P44L	TCGA-19-1387	GBM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-A5-A0GQ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-AX-A064	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-B5-A1MV	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-BG-A0MQ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-D1-A15W	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-D3-A8GB	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-DI-A1BY	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	TCGA-SJ-A6ZJ	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO11573	GBM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO48344	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO231437	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO231540	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO48841	NBL	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO227650	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO227915	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO35690	PBCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO50280	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO219785	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO43402	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO43354	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO43073	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO41127	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO42857	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO41404	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO220979	WT	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	DO221104	WT	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	SIDM00342	T-Lymphoblastic Leukemia	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	ACH-000104	Leukemia	CCLE	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.P44L	LOUCY	haematopoietic and lymphoid tissue	COSMIC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7582
p.T58M	TCGA-26-5136	GBM	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8534
p.T58M	DO11471	GBM	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8534
p.T58M	DO231615	NBL	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8534
p.D34E	TCGA-AP-A1DV	UCEC	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.1667
p.D34E	DO43186	UCEC	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.1667
p.T58K	TCGA-BG-A2L7	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8417
p.T58K	DO42344	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8417
p.S42L	TCGA-D3-A51R	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6556
p.S42L	DO47480	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6556
p.D31N	TCGA-EE-A20C	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.0833
p.D31N	DO222775	MELA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.0833
p.D31N	DO47665	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.0833
p.P40T	TCGA-EE-A2MK	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7031
p.P40T	DO38177	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.7031
p.G46R	TCGA-EE-A3JD	SKCM	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6457
p.G46R	DO50299	SKCM	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6457
p.P45L	TCGA-F1-6874	STAD	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6471
p.P45L	DO38201	STAD	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation altering degron motif	0.6471
p.I49M	TCGA-GC-A6I3	BLCA	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.I49M	TCGA-GC-A6I3	BLCA	TCGA	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.2778
p.I49M	DO219025	BLCA	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.I49M	DO219025	BLCA	ICGC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.2778
p.H70L	TCGA-MN-A4N4	LUAD	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.H70L	DO26250	LUAD	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.T259N	DO228262	BRCA	ICGC	ALSTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.2222
p.R242H	DO233207	GACA	ICGC	ALSTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.E69K	DO50802	LIRI	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.H70N	DO50662	ORCA	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.R242L	DO50425	PRAD	ICGC	ALSTS	DEG_SPOP_SBC_1	251:255	Mutation rewiring degron network	0.0833
p.P57H	SIDM00789	Colorectal Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.P57H	ACH-000997	Colon/Colorectal Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.P57H	HCT-15	large intestine	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.F37L	SIDM00013	Melanoma	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.25
p.F37L	SIDM00265	Ewing's Sarcoma	GDSC	PDSTPPGE	DEG_SCF_FBW7_2	40:47	Mutation rewiring degron network	0.25
p.L61P	SIDM00901	Endometrial Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6471
p.L61P	ACH-000940	Endometrial/Uterine Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6471
p.L61P	AN3-CA	endometrium	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6471
p.E59Q	ZR-75-30	breast	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6744
p.I66F	639-V	urinary tract	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.R251Q	SNU-175	large intestine	COSMIC	ALSTS	DEG_SPOP_SBC_1	251:255	Mutation altering degron motif	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYCN

UniProt ID: P04198

Entrez ID: 4613

Protein name: N-myc proto-oncogene protein (Class E basic helix-loop-helix protein 37) (bHLHe37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYCN in