DegronMD

Uniprot ID: P04198

Source protein: N-myc proto-oncogene protein

Source gene: MYCN

Class: DEG_SCF_FBW7_1

Location: 55:62

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 52.1375

COIL: 0.9309

CONS_SCORE: 0.8804

DSS_SCORE: 0.4702

HELIX: 0.0241

FCONS_SCORE: 1.3418

RIG_SCORE: 0.7001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T58M	TCGA-26-5136	GBM	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.8534
p.T58M	DO11471	GBM	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.8534
p.T58M	DO231615	NBL	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.8534
p.T58K	TCGA-BG-A2L7	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.8417
p.T58K	DO42344	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.8417
p.I49M	TCGA-GC-A6I3	BLCA	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.I49M	DO219025	BLCA	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.H70L	TCGA-MN-A4N4	LUAD	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.1111
p.H70L	DO26250	LUAD	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1111
p.E69K	DO50802	LIRI	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1389
p.H70N	DO50662	ORCA	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1111
p.P57H	SIDM00789	Colorectal Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P57H	ACH-000997	Colon/Colorectal Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P57H	HCT-15	large_intestine	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.L61P	SIDM00901	Endometrial Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6471
p.L61P	ACH-000940	Endometrial/Uterine Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6471
p.L61P	AN3-CA	endometrium	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6471
p.E59Q	ZR-75-30	breast	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6744
p.I66F	639-V	urinary_tract	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons