DegronMD

Uniprot ID: P01106

Source protein: Myc proto-oncogene protein

Source gene: MYC

Class: DEG_SCF_FBW7_1

Location: 55:62

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 52.9875

COIL: 0.9493

CONS_SCORE: 0.5009

DSS_SCORE: 0.461

HELIX: 0.0168

FCONS_SCORE: 1.0592

RIG_SCORE: 0.6876

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K66N	TCGA-75-6214	LUAD	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.2222
p.K66N	DO24830	LUAD	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.2222
p.A59V	TCGA-BG-A220	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	TCGA-E6-A2P8	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	TCGA-N7-A4Y0	UCS	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	DO52691	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	DO40924	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	DO41784	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.A59V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6936
p.E54D	TCGA-FF-8046	DLBC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	DO222303	DLBC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	DO228287	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	DO228338	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	SIDM00948	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.P72S	DO27821	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	DO228242	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	DO228349	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SIDM00907	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SIDM01254	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72S	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.Q49H	DO27775	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.Q49H	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.Q50L	DO27775	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1944
p.Q50L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1944
p.Q52E	DO228338	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.6944
p.Q52E	SIDM00948	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6944
p.Q52E	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6944
p.P72A	DO228387	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72L	DO228387	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.A59T	DO52671	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.7139
p.A59T	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.7139
p.A59T	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.7139
p.F46L	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0833
p.P72T	DO228578	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	SIDM01198	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	SIDM00854	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72T	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.Q50H	DO52658	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	0.1944
p.Q50H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1944
p.N45S	SIDM00683	Prostate Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.N45S	LNCaP-Clone-FGC	prostate	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72H	SIDM00074	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P72H	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.Y47H	SIDM00074	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.1111
p.Q51H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.Q51H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.Q51L	SIDM01198	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.Q51L	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.Q52K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.6944
p.Q52K	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6944
p.E69K	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	0.1389
p.E69K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1389
p.T58N	ACH-000151	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.8166
p.T58N	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.8166
p.P60T	ACH-000157	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P60T	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.L69I	ACH-000157	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.1389
p.L69I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1389
p.P57T	ACH-000162	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	ACH-000271	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	ACH-000567	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	ACH-001680	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P57T	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5919
p.P59L	ACH-000218	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.7582
p.P59L	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.7582
p.P63S	ACH-000285	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.S64R	ACH-000285	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.7222
p.T58I	ACH-000287	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T58I	ACH-000402	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T58I	ACH-000654	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T58I	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T58I	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.8189
p.P59A	ACH-000388	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.7503
p.P57H	ACH-000402	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P57H	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P57S	ACH-000440	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	ACH-000656	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	ACH-000707	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	ACH-001616	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	ACH-002055	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	ACH-002392	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P57S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5641
p.P60H	ACH-000440	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P60H	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6583
p.P60A	ACH-000660	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6392
p.P60A	ACH-001703	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6392
p.P60A	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6392
p.P60A	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6392
p.E54K	ACH-000841	Lung Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.E54K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.3056
p.T58A	ACH-000877	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.825
p.T58A	ACH-001064	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.825
p.T58A	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.825
p.T58A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.825
p.P59S	ACH-000944	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6752
p.P59S	ACH-002221	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6752
p.P59S	ACH-002272	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6752
p.P59S	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6752
p.P57L	ACH-001616	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.6471
p.P59Q	ACH-001656	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.7035
p.S62P	ACH-002293	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	0.7863
p.S62P	P32-ISH	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.7863
p.Q51E	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.D49H	JiyoyeP-2003	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.P71T	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.P71T	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.P71T	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.P71T	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.T72N	JM1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.T72I	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.T72I	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.Q51K	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.6667
p.T72A	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.T72A	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.0556
p.P71S	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.P71S	CA46	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.P71S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.A58T	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.7139
p.E53D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.2778
p.E53D	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.2778
p.P71H	BL-70	haematopoietic_and_lymphoid_tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.5278
p.E68K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.1667
p.A53V	YAPC	pancreas	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLPTPPLS

Degron related mutations and impact score

Drug responses associated with MYC mutations

All proteins holding degron of LLPTPPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01106	Myc proto-oncogene protein	DEG_SCF_FBW7_1	55:62	LLPTPPLS	FBXW7	0.9991	More...
P04198	N-myc proto-oncogene protein	DEG_SCF_FBW7_1	55:62	LLPTPPLS	FBXW7	0.9992	More...