DegronMD - P01106(MYC)

GO - Biological processes (BP): amino acid transport [GO:0006865]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell population proliferation [GO:0008283]; cellular iron ion homeostasis [GO:0006879]; cellular response to angiotensin [GO:1904385]; cellular response to arsenite(3-) [GO:1903841]; cellular response to carbohydrate stimulus [GO:0071322]; cellular response to cycloheximide [GO:0071409]; cellular response to dimethyl sulfoxide [GO:1904620]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to endothelin [GO:1990859]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to estrogen stimulus [GO:0071391]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to growth hormone stimulus [GO:0071378]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-1 [GO:0071347]; cellular response to lectin [GO:1990858]; cellular response to phorbol 13-acetate 12-myristate [GO:1904628]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to prolactin [GO:1990646]; cellular response to putrescine [GO:1904586]; cellular response to retinoic acid [GO:0071300]; cellular response to testosterone stimulus [GO:0071394]; cellular response to UV [GO:0034644]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; chromosome organization [GO:0051276]; DNA-templated transcription, initiation [GO:0006352]; energy reserve metabolic process [GO:0006112]; ERK1 and ERK2 cascade [GO:0070371]; fibroblast apoptotic process [GO:0044346]; G0 to G1 transition [GO:0045023]; G1/S transition of mitotic cell cycle [GO:0000082]; glucose metabolic process [GO:0006006]; hypothalamus development [GO:0021854]; inner mitochondrial membrane organization [GO:0007007]; in utero embryonic development [GO:0001701]; lactic acid secretion [GO:0046722]; liver regeneration [GO:0097421]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell division [GO:0051782]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; negative regulation of monocyte differentiation [GO:0045656]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription by RNA polymerase II [GO:0000122]; ovarian follicle development [GO:0001541]; ovulation [GO:0030728]; oxygen transport [GO:0015671]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA methylation [GO:1905643]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of glycolytic process [GO:0045821]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of metanephric cap mesenchymal cell proliferation [GO:0090096]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of mitochondrial membrane potential [GO:0010918]; positive regulation of oxidative phosphorylation [GO:1903862]; positive regulation of response to DNA damage stimulus [GO:2001022]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-DNA complex disassembly [GO:0032986]; pyruvate transport [GO:0006848]; re-entry into mitotic cell cycle [GO:0000320]; regulation of cell cycle process [GO:0010564]; regulation of gene expression [GO:0010468]; regulation of mitotic cell cycle [GO:0007346]; regulation of somatic stem cell population maintenance [GO:1904672]; regulation of telomere maintenance [GO:0032204]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to gamma radiation [GO:0010332]; response to growth factor [GO:0070848]; response to human chorionic gonadotropin [GO:0044752]; response to wounding [GO:0009611]; response to xenobiotic stimulus [GO:0009410]; transcription by RNA polymerase II [GO:0006366] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q321E	TCGA-66-2785	LUSC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.Q321E	DO26520	LUSC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.S161L	TCGA-69-8253	LUAD	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-A6-5659	COAD	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-CV-A45V	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-D6-6825	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-DS-A1OB	CESC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-EE-A182	SKCM	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-H7-8501	HNSC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	TCGA-SS-A7HO	COAD	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO233964	BPLL	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO6323	CESC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO223485	CLLE	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO223705	COAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO9860	COAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO14630	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO14202	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO52059	HNSC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO23637	LUAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO233554	PRAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.S161L	DO37814	SKCM	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation blocking phosphorylation signal	0.5278
p.K66N	TCGA-75-6214	LUAD	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.K66N	DO24830	LUAD	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2222
p.L164V	TCGA-77-7139	LUSC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO27636	LUSC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO27819	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO27793	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO228338	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO228368	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO52692	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO228478	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO228406	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DO228829	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	SIDM00985	Burkitt's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	SIDM00948	Burkitt's Lymphoma	GDSC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DG-75	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	BL-41	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.L164V	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.P233T	TCGA-B6-A0I1	BRCA	TCGA	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.P233T	DO4138	BRCA	ICGC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.A180T	TCGA-BC-A10Z	LIHC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.A180T	DO23043	LIHC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.A59V	TCGA-BG-A220	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	TCGA-E6-A2P8	UCEC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	TCGA-N7-A4Y0	UCS	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	DO52691	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	DO40924	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	DO41784	UCEC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.A59V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6936
p.V340D	TCGA-D1-A103	UCEC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.0833
p.V340D	DO42312	UCEC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.0833
p.P233Q	TCGA-ER-A195	SKCM	TCGA	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.P233Q	DO47712	SKCM	ICGC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.K341R	TCGA-EY-A1GK	UCEC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation substituting flanking lysine	0.1667
p.K341R	DO42985	UCEC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation substituting flanking lysine	0.1667
p.E54D	TCGA-FF-8046	DLBC	TCGA	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	DO222303	DLBC	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	DO228287	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	DO228338	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	SIDM00948	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54D	DG-75	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.Q321H	TCGA-FF-8046	DLBC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.Q321H	DO222303	DLBC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.Q321H	SIDM00907	Burkitt's Lymphoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.Q321H	ACH-000440	Lymphoma	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.Q321H	CA46	haematopoietic and lymphoid tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.S184C	TCGA-GS-A9TV	DLBC	TCGA	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.S184C	DO219914	DLBC	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.S329F	TCGA-JW-A5VL	CESC	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7982
p.S329F	DO49976	CESC	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7982
p.A326G	TCGA-KK-A8IK	PRAD	TCGA	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.754
p.A326G	DO219339	PRAD	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.754
p.R181H	DO48448	BLCA	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.V160L	DO234452	BPLL	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0556
p.N178K	DO230316	COCA	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.T330A	DO234300	ESAD	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7139
p.P327L	DO233937	GACA	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7582
p.V317F	DO229032	LICA	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation substituting flanking lysine	0.2778
p.P72S	DO27821	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	DO228242	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	DO228349	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SIDM00907	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SIDM01254	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	CA46	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72S	SC-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.L255F	DO228285	MALY	ICGC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1667
p.Q49H	DO27775	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.Q49H	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.Q50L	DO27775	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.Q50L	ST486	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.Q52E	DO228338	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6944
p.Q52E	SIDM00948	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6944
p.Q52E	DG-75	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6944
p.C315S	DO52683	MALY	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1111
p.S318A	DO52683	MALY	ICGC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1944
p.P72A	DO228387	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72L	DO228387	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.A59T	DO52671	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7139
p.A59T	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7139
p.A59T	SC-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7139
p.F46L	DO228417	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0833
p.P72T	DO228578	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	SIDM01198	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	SIDM00854	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	ST486	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72T	GA-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.Y167N	DO221117	MALY	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.Q50H	DO52658	MALY	ICGC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.Q50H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1944
p.E257V	DO232838	NACA	ICGC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1111
p.P177R	DO48577	PRAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.G175D	DO38404	STAD	ICGC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.3056
p.N45S	SIDM00683	Prostate Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.N45S	LNCaP-Clone-FGC	prostate	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.E251K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.E251K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.E251K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.E251K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.P72H	SIDM00074	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.P72H	BL-70	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.Y47H	SIDM00074	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1111
p.Q51H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.Q51H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.A336V	SIDM01090	Colorectal Carcinoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1944
p.A336V	ACH-000943	Colon/Colorectal Cancer	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1944
p.A336V	RKO	large intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1944
p.Q51L	SIDM01198	Burkitt's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.Q51L	ST486	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.P250L	SIDM00504	Glioma	GDSC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation blocking phosphorylation signal	0.75
p.P250L	SIDM00504	Glioma	GDSC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation blocking phosphorylation signal	0.5833
p.P250L	MOG-G-UVW	central nervous system	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation blocking phosphorylation signal	0.75
p.P250L	MOG-G-UVW	central nervous system	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation blocking phosphorylation signal	0.5833
p.Q52K	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6944
p.Q52K	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6944
p.Q168R	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2778
p.Q168R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2778
p.E69K	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.E69K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.N323S	SIDM00498	Colorectal Carcinoma	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7069
p.N323S	ACH-000970	Colon/Colorectal Cancer	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7069
p.N323S	SNU-C5	large intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation altering degron motif	0.7069
p.D236H	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.D236H	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2778
p.D236H	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.D236H	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2778
p.C315Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1111
p.C315Y	ACH-000937	Leukemia	CCLE	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1111
p.C315Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.1111
p.T58N	ACH-000151	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8166
p.T58N	JM1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8166
p.P60T	ACH-000157	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P60T	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.L69I	ACH-000157	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.L69I	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1389
p.P57T	ACH-000162	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	ACH-000271	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	ACH-000567	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	ACH-001680	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	ST486	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	GA-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P57T	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5919
p.P59L	ACH-000218	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7582
p.P59L	PL-21	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7582
p.D251N	ACH-000245	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.D251N	ACH-000245	Lymphoma	CCLE	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.D251N	ACH-002275	Leukemia	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.D251N	ACH-002275	Leukemia	CCLE	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.D251N	MN-60	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.D251N	MN-60	haematopoietic and lymphoid tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.D251N	BL-41	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2778
p.D251N	BL-41	haematopoietic and lymphoid tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.P63S	ACH-000285	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.S64R	ACH-000285	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.7222
p.T58I	ACH-000287	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8189
p.T58I	ACH-000402	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8189
p.T58I	ACH-000654	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8189
p.T58I	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8189
p.T58I	BL-70	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.8189
p.S182T	ACH-000287	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.S182T	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.P59A	ACH-000388	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7503
p.P57H	ACH-000402	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.P57H	BL-70	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.P57S	ACH-000440	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	ACH-000656	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	ACH-000707	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	ACH-001616	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	ACH-002055	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	ACH-002392	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	SC-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	CA46	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P57S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.5641
p.P60H	ACH-000440	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.P60H	CA46	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6583
p.L178V	ACH-000440	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.L178V	CA46	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.2222
p.E236K	ACH-000562	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.E236K	ACH-000562	Lung Cancer	CCLE	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2778
p.E236K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0833
p.E236K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2778
p.A183V	ACH-000567	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0833
p.A183V	ST486	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.0833
p.P60A	ACH-000660	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6392
p.P60A	ACH-001703	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6392
p.P60A	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6392
p.P60A	VAL	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6392
p.S175T	ACH-000687	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.3056
p.S174T	ACH-000706	Lung Cancer	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.6005
p.S174T	EKVX	lung	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.6005
p.E54K	ACH-000841	Lung Cancer	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.E54K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.3056
p.T58A	ACH-000877	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.825
p.T58A	ACH-001064	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.825
p.T58A	ROS-50	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.825
p.T58A	EB2	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.825
p.P59S	ACH-000944	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6752
p.P59S	ACH-002221	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6752
p.P59S	ACH-002272	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6752
p.P59S	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6752
p.S249R	ACH-000944	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.8538
p.S249R	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.8538
p.P235L	ACH-001126	Brain Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.P235L	ACH-001126	Brain Cancer	CCLE	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.25
p.P235L	MOG-G-UVW	central nervous system	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.P235L	MOG-G-UVW	central nervous system	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.25
p.C171W	ACH-001450	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.5889
p.P57L	ACH-001616	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.6471
p.P59Q	ACH-001656	Leukemia	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7035
p.Y177H	ACH-001680	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.Y177H	U-698-M	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.Q179H	ACH-001680	Lymphoma	CCLE	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.Q179H	U-698-M	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1944
p.S252C	ACH-001680	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation blocking phosphorylation signal	0.6944
p.S252C	ACH-001680	Lymphoma	CCLE	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation blocking phosphorylation signal	0.5278
p.S252C	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation blocking phosphorylation signal	0.6944
p.S252C	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation blocking phosphorylation signal	0.5278
p.S249N	ACH-001685	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.818
p.S62P	ACH-002293	Lymphoma	CCLE	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7863
p.S62P	P32-ISH	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7863
p.Q51E	DG-75	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.C314Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.0833
p.R182S	Ramos-2G6-4C10	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1111
p.E250K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation blocking phosphorylation signal	0.75
p.E250K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation blocking phosphorylation signal	0.5833
p.L163V	DG-75	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.L163V	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.L163V	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.L163V	BL-41	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1389
p.D49H	JiyoyeP-2003	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.V253L	TE-9	oesophagus	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2222
p.V253L	TE-9	oesophagus	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.P71T	GA-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P71T	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P71T	ST486	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P71T	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P249L	MOG-G-UVW	central nervous system	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7582
p.D235H	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.D235H	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.25
p.T72N	JM1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.V254L	TE-9	oesophagus	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.T72I	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.T72I	BL-70	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.G253R	H3118	upper aerodigestive tract	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2222
p.G253R	H3118	upper aerodigestive tract	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.Q51K	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking ubiquitination signal	0.6667
p.L180M	VAL	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.T72A	EB2	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.T72A	ROS-50	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.0556
p.V239L	TE-9	oesophagus	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.5654
p.Q167R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.25
p.S234P	JHOS-4	ovary	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2222
p.L180V	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation rewiring degron network	0.1667
p.Q335R	NCCIT	testis	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2222
p.P71S	SC-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P71S	CA46	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.P71S	SU-DHL-8	NS	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.A58T	SC-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation altering degron motif	0.7139
p.A321V	RKO	large intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2778
p.N322S	SNU-C5	large intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.3056
p.E253K	H3118	upper aerodigestive tract	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.2222
p.E253K	H3118	upper aerodigestive tract	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.S235P	JHOS-4	ovary	COSMIC	PPTTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.S235P	JHOS-4	ovary	COSMIC	LVLHEE	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.25
p.E53D	DG-75	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778
p.E53D	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778
p.Q320H	CA46	haematopoietic and lymphoid tissue	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.25
p.P71H	BL-70	haematopoietic and lymphoid tissue	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation blocking phosphorylation signal	0.5278
p.R171H	EB2	haematopoietic and lymphoid tissue	COSMIC	VCSTS	DEG_SPOP_SBC_1	170:174	Mutation altering degron motif	0.8244
p.E68K	NCI-H2087	lung	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.1667
p.A335V	RKO	large intestine	COSMIC	KRVKLDSVR	DEG_APCC_DBOX_1	323:331	Mutation rewiring degron network	0.2222
p.A53V	YAPC	pancreas	COSMIC	LLPTPPLS	DEG_SCF_FBW7_1	55:62	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYC

UniProt ID: P01106

Entrez ID: 4609

Protein name: Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYC in