DegronMD

Uniprot ID: P01106

Source protein: Myc proto-oncogene protein

Source gene: MYC

Class: LIG_APCC_ABBA_1

Location: 238:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7738

ASA_SCORE: 100.1833

COIL: 0.8142

CONS_SCORE: 0.3129

DSS_SCORE: 0.8932

HELIX: 0.1342

FCONS_SCORE: 0.8581

RIG_SCORE: 0.6125

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P233T	TCGA-B6-A0I1	BRCA	TCGA	LVLHEE	LIG_APCC_ABBA_1	0.1944
p.P233T	DO4138	BRCA	ICGC	LVLHEE	LIG_APCC_ABBA_1	0.1944
p.P233Q	TCGA-ER-A195	SKCM	TCGA	LVLHEE	LIG_APCC_ABBA_1	0.1944
p.P233Q	DO47712	SKCM	ICGC	LVLHEE	LIG_APCC_ABBA_1	0.1944
p.E251K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.E251K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.P250L	SIDM00504	Glioma	GDSC	LVLHEE	LIG_APCC_ABBA_1	0.5833
p.P250L	MOG-G-UVW	central_nervous_system	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.5833
p.D236H	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LVLHEE	LIG_APCC_ABBA_1	0.2778
p.D236H	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.2778
p.D251N	ACH-000245	Lymphoma	CCLE	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.D251N	ACH-002275	Leukemia	CCLE	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.D251N	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.D251N	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.1111
p.E236K	ACH-000562	Lung Cancer	CCLE	LVLHEE	LIG_APCC_ABBA_1	0.2778
p.E236K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.2778
p.P235L	ACH-001126	Brain Cancer	CCLE	LVLHEE	LIG_APCC_ABBA_1	0.25
p.P235L	MOG-G-UVW	central_nervous_system	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.25
p.S252C	ACH-001680	Lymphoma	CCLE	LVLHEE	LIG_APCC_ABBA_1	0.5278
p.S252C	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.5278
p.E250K	HCC-78	lung	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.5833
p.V253L	TE-9	oesophagus	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.0556
p.D235H	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.25
p.G253R	H3118	upper_aerodigestive_tract	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.0556
p.V239L	TE-9	oesophagus	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.5654
p.S234P	JHOS-4	ovary	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.2222
p.E253K	H3118	upper_aerodigestive_tract	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.0556
p.S235P	JHOS-4	ovary	COSMIC	LVLHEE	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVLHEE

Degron related mutations and impact score

Drug responses associated with MYC mutations

All proteins holding degron of LVLHEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P01106	Myc proto-oncogene protein	LIG_APCC_ABBA_1	238:243	LVLHEE	APC,CDC20,FZR1	0.7738	More...