DegronMD

Uniprot ID: P01106

Source protein: Myc proto-oncogene protein

Source gene: MYC

Class: DEG_SPOP_SBC_1

Location: 245:249

E3 ligase: SPOP

DEGRON score: 0.9673

ASA_SCORE: 96.32

COIL: 0.9676

CONS_SCORE: 0.3103

DSS_SCORE: 0.9034

HELIX: 0.0204

FCONS_SCORE: 0.7618

RIG_SCORE: 0.5473

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S249R	ACH-000944	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	0.8538
p.S249R	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.8538
p.S249N	ACH-001685	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	0.818
p.P249L	MOG-G-UVW	central_nervous_system	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.7582
p.P250L	SIDM00504	Glioma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.75
p.P250L	MOG-G-UVW	central_nervous_system	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.75
p.E250K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.75
p.S252C	ACH-001680	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	0.6944
p.S252C	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.6944
p.E251K	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.2778
p.E251K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2778
p.D251N	ACH-000245	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	0.2778
p.D251N	ACH-002275	Leukemia	CCLE	PPTTS	DEG_SPOP_SBC_1	0.2778
p.D251N	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2778
p.D251N	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2778
p.V253L	TE-9	oesophagus	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.G253R	H3118	upper_aerodigestive_tract	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.E253K	H3118	upper_aerodigestive_tract	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.V254L	TE-9	oesophagus	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.L255F	DO228285	MALY	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1667
p.E257V	DO232838	NACA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1111
p.D236H	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.D236H	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.E236K	ACH-000562	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.0833
p.E236K	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 25 of 29 entries

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Drug responses associated with MYC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPTTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86VF5	2-acylglycerol O-acyltransferase 3	DEG_SPOP_SBC_1	9:13	PPTTS	SPOP	0.9231	More...
Q96Q42	Alsin	DEG_SPOP_SBC_1	384:388	PPTTS	SPOP	0.957	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	444:448	PPTTS	SPOP	0.9481	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	400:404	PPTTS	SPOP	0.9764	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SPOP_SBC_1	196:200	PPTTS	SPOP	0.9868	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	921:925	PPTTS	SPOP	0.9871	More...
Q8NC54	Keratinocyte-associated transmembrane protein 2	DEG_SPOP_SBC_1	89:93	PPTTS	SPOP	0.9928	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	66:70	PPTTS	SPOP	0.9159	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1492:1496	PPTTS	SPOP	0.7371	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3135:3139	PPTTS	SPOP	0.6836	More...
P01106	Myc proto-oncogene protein	DEG_SPOP_SBC_1	245:249	PPTTS	SPOP	0.9673	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	387:391	PPTTS	SPOP	0.9613	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	353:357	PPTTS	SPOP	0.8488	More...
Q12857	Nuclear factor 1 A-type	DEG_SPOP_SBC_1	458:462	PPTTS	SPOP	0.9881	More...
Q16549	Proprotein convertase subtilisin/kexin type 7	DEG_SPOP_SBC_1	741:745	PPTTS	SPOP	0.9748	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	73:77	PPTTS	SPOP	0.8424	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	851:855	PPTTS	SPOP	0.9986	More...
O95755	Ras-related protein Rab-36	DEG_SPOP_SBC_1	21:25	PPTTS	SPOP	0.8571	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	923:927	PPTTS	SPOP	0.6646	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_SPOP_SBC_1	216:220	PPTTS	SPOP	0.7106	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTS

Degron related mutations and impact score

Drug responses associated with MYC mutations

All proteins holding degron of PPTTS