DegronMD - Q92954(PRG4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P778L	TCGA-05-4427	LUAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7582
p.P778L	DO23666	LUAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7582
p.A697V	TCGA-06-5416	GBM	TCGA	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.3056
p.A697V	TCGA-06-5416	GBM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.A697V	DO10880	GBM	ICGC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.3056
p.A697V	DO10880	GBM	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.G223E	TCGA-19-5956	GBM	TCGA	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.G223E	DO13863	GBM	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.L717P	TCGA-24-1470	OV	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1944
p.L717P	DO28010	OV	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1944
p.P363H	TCGA-33-4532	LUSC	TCGA	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.3056
p.P363H	DO26626	LUSC	ICGC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.3056
p.P508H	TCGA-33-4566	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.6583
p.P508H	DO26790	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.6583
p.T781I	TCGA-34-8455	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7078
p.T781I	DO50095	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7078
p.T807N	TCGA-35-5375	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7055
p.T807N	DO25290	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation altering degron motif	0.7055
p.P522T	TCGA-44-6144	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.3056
p.P522T	TCGA-44-6144	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.1111
p.P522T	DO24190	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.3056
p.P522T	DO24190	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.1111
p.P873H	TCGA-44-7670	LUAD	TCGA	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.0556
p.P873H	DO23555	LUAD	ICGC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.0556
p.T527S	TCGA-46-6026	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.6005
p.T527S	DO26740	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.6005
p.T861N	TCGA-49-AAR9	LUAD	TCGA	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation altering degron motif	0.5944
p.T861N	DO218921	LUAD	ICGC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation altering degron motif	0.5944
p.P404T	TCGA-49-AARE	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.P404T	TCGA-49-AARE	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0833
p.P404T	DO218922	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.25
p.P404T	DO218922	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.0833
p.T715A	TCGA-4R-AA8I	LIHC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.25
p.T715A	DO49657	LIHC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.25
p.P836R	TCGA-55-7910	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.0556
p.P836R	DO23669	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.0556
p.E615K	TCGA-55-8094	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.591
p.E615K	TCGA-W3-AA1Q	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.591
p.E615K	DO24150	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.591
p.E615K	DO219487	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.591
p.P519L	TCGA-55-A490	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1111
p.P519L	TCGA-55-A490	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2222
p.P519L	DO24596	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1111
p.P519L	DO24596	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2222
p.P765T	TCGA-60-2714	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	TCGA-60-2714	LUSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	DO26530	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	DO26530	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	SIDM00107	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	SIDM00107	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P765T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1111
p.P765T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.T532S	TCGA-66-2793	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	530:534	Mutation altering degron motif	0.6005
p.T532S	DO27334	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation altering degron motif	0.6005
p.D917H	TCGA-83-5908	LUAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.1389
p.D917H	DO23572	LUAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.1389
p.A421G	TCGA-85-A53L	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.754
p.A421G	DO45459	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.754
p.P818H	TCGA-86-8073	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.2778
p.P818H	TCGA-86-8073	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2222
p.P818H	DO23624	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.2778
p.P818H	DO23624	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2222
p.A389T	TCGA-86-A4JF	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.25
p.A389T	TCGA-86-A4JF	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.A389T	DO45317	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.25
p.A389T	DO45317	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.P722H	TCGA-99-AA5R	LUAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P722H	DO51203	LUAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.E764G	TCGA-A2-A0CR	BRCA	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	TCGA-AB-2849	LAML	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	DO44163	BRCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	DO21403	LAML	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	DO231003	LUSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	ACH-000810	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.P605H	TCGA-A4-7583	KIRP	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1944
p.P605H	TCGA-A4-7583	KIRP	TCGA	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.P605H	DO20870	KIRP	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1944
p.P605H	DO20870	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.E950K	TCGA-AG-3892	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	TCGA-AP-A056	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	TCGA-DF-A2KU	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	TCGA-EI-6917	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	DO232761	PBCA	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	DO36394	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	DO36881	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	DO223286	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	DO43971	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	SIDM01611	Endometrial Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	SIDM01588	Endometrial Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	ACH-000993	Endometrial/Uterine Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.E950K	ACH-000996	Endometrial/Uterine Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0556
p.A397T	TCGA-AN-A0AK	BRCA	TCGA	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7139
p.A397T	DO1608	BRCA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7139
p.K614N	TCGA-AP-A0LM	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.5806
p.K614N	DO43306	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.5806
p.P720S	TCGA-AP-A1DV	UCEC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.P720S	DO43186	UCEC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1111
p.K840N	TCGA-AX-A05Z	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation substituting flanking lysine	0.25
p.K840N	DO40884	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation substituting flanking lysine	0.25
p.D923E	TCGA-AX-A05Z	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923E	TCGA-AX-A05Z	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.D923E	DO40884	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923E	DO40884	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.G341S	TCGA-AX-A06F	UCEC	TCGA	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1944
p.G341S	TCGA-AX-A06F	UCEC	TCGA	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.G341S	DO41752	UCEC	ICGC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1944
p.G341S	DO41752	UCEC	ICGC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.K817T	TCGA-AX-A0J0	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation substituting flanking lysine	0.3611
p.K817T	TCGA-AX-A0J0	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation substituting flanking lysine	0.1667
p.K817T	TCGA-AX-A0J0	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation substituting flanking lysine	0.3611
p.K817T	DO41133	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation substituting flanking lysine	0.3611
p.K817T	DO41133	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation substituting flanking lysine	0.1667
p.K817T	DO41133	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation substituting flanking lysine	0.3611
p.P605L	TCGA-AX-A1CE	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1944
p.P605L	TCGA-AX-A1CE	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.P605L	DO42280	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1944
p.P605L	DO42280	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.E349G	TCGA-B0-4823	KIRC	TCGA	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.E349G	TCGA-B0-4823	KIRC	TCGA	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.E349G	DO18492	KIRC	ICGC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.E349G	DO18492	KIRC	ICGC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.E591G	TCGA-B5-A0K9	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.E591G	DO42097	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.R925H	TCGA-B5-A3FA	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation altering degron motif	0.7133
p.R925H	DO52402	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation altering degron motif	0.7133
p.L981H	TCGA-BH-A0WA	BRCA	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.0833
p.L981H	DO2897	BRCA	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.0833
p.T510A	TCGA-BR-4368	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7139
p.T510A	DO38715	STAD	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7139
p.K726N	TCGA-BS-A0UF	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.2222
p.K726N	DO41488	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.2222
p.D923Y	TCGA-BS-A0UV	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923Y	TCGA-BS-A0UV	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.D923Y	DO42793	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923Y	DO42793	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.T752I	TCGA-CG-5733	STAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7078
p.T752I	DO38551	STAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7078
p.S427Y	TCGA-CK-4948	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.5
p.S427Y	TCGA-CK-4948	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	421:425	Mutation blocking phosphorylation signal	0.7222
p.S427Y	DO10598	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.5
p.S427Y	DO10598	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation blocking phosphorylation signal	0.7222
p.P754R	TCGA-CR-7386	HNSC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7512
p.P754R	DO14348	HNSC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.7512
p.G223A	TCGA-CV-7437	HNSC	TCGA	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.G223A	DO14902	HNSC	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.K426N	TCGA-D1-A103	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	413:417	Mutation substituting flanking lysine	0.1944
p.K426N	DO42312	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation substituting flanking lysine	0.1944
p.E801K	TCGA-D1-A17Q	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.E801K	TCGA-D1-A17Q	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.E801K	TCGA-W3-AA1V	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.E801K	TCGA-W3-AA1V	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.E801K	DO51276	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.E801K	DO51276	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.E801K	DO41903	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.E801K	DO41903	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.0833
p.P839H	TCGA-DF-A2KN	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.1111
p.P839H	DO223282	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.1111
p.A933V	TCGA-DF-A2KU	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.2778
p.A933V	TCGA-DF-A2KU	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.3056
p.A933V	DO223286	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.2778
p.A933V	DO223286	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.3056
p.E940Q	TCGA-DK-A6B6	BLCA	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.0833
p.E940Q	TCGA-DK-A6B6	BLCA	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.E940Q	DO48576	BLCA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.0833
p.E940Q	DO48576	BLCA	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1111
p.S360F	TCGA-E2-A2P6	BRCA	TCGA	PASTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.7982
p.S360F	DO4173	BRCA	ICGC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.7982
p.E349K	TCGA-EE-A29D	SKCM	TCGA	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.E349K	TCGA-EE-A29D	SKCM	TCGA	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.E349K	DO38123	SKCM	ICGC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.E349K	DO38123	SKCM	ICGC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.E833K	TCGA-EE-A29R	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.1389
p.E833K	TCGA-ER-A194	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.1389
p.E833K	DO37448	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.1389
p.E833K	DO47646	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation rewiring degron network	0.1389
p.E434K	TCGA-EE-A2GO	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.E434K	DO37823	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.K599Q	TCGA-EE-A3AG	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599Q	DO37471	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.P626L	TCGA-EI-6510	READ	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0556
p.P626L	DO36387	READ	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0556
p.K771T	TCGA-EO-A3AY	UCEC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation substituting flanking lysine	0.3333
p.K771T	DO43202	UCEC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation substituting flanking lysine	0.3333
p.K918N	TCGA-EO-A3B0	UCEC	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.2778
p.K918N	TCGA-EO-A3B0	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.1667
p.K918N	DO219773	UCEC	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.2778
p.K918N	DO219773	UCEC	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.1667
p.K972E	TCGA-EO-A3B0	UCEC	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation altering degron motif	0.7022
p.K972E	DO219773	UCEC	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation altering degron motif	0.7022
p.P698A	TCGA-ER-A19B	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.7503
p.P698A	DO47491	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.7503
p.P725L	TCGA-EY-A215	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.P725L	DO42665	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.E856D	TCGA-EY-A215	UCEC	TCGA	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.25
p.E856D	TCGA-EY-A215	UCEC	TCGA	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.3056
p.E856D	TCGA-EY-A215	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.E856D	DO233729	GACA	ICGC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.25
p.E856D	DO233729	GACA	ICGC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.3056
p.E856D	DO233729	GACA	ICGC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.E856D	DO42665	UCEC	ICGC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.25
p.E856D	DO42665	UCEC	ICGC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.3056
p.E856D	DO42665	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.A798V	TCGA-FI-A2D5	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.A798V	DO41331	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.1944
p.P613R	TCGA-GN-A26D	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7512
p.P613R	DO37480	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7512
p.P546S	TCGA-HT-8109	LGG	TCGA	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.2222
p.P546S	DO22183	LGG	ICGC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.2222
p.P789H	TCGA-HU-A4H8	STAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.P789H	DO47869	STAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.T781P	TCGA-IB-7651	PAAD	TCGA	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7031
p.T781P	DO46657	PAAD	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.7031
p.D923N	TCGA-IB-7651	PAAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923N	TCGA-IB-7651	PAAD	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.D923N	DO46657	PAAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.D923N	DO46657	PAAD	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.K504N	TCGA-P3-A6T2	HNSC	TCGA	APTTT	DEG_SPOP_SBC_1	507:511	Mutation substituting flanking lysine	0.3611
p.K504N	DO49034	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation substituting flanking lysine	0.3611
p.P799H	TCGA-PG-A917	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2222
p.P799H	DO52424	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2222
p.S249F	TCGA-Q1-A73O	CESC	TCGA	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.S249F	TCGA-Q1-A73O	CESC	TCGA	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0833
p.S249F	DO51612	CESC	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.0556
p.S249F	DO51612	CESC	ICGC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0833
p.G711E	TCGA-QC-A7B5	SARC	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6087
p.G711E	DO220239	SARC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6087
p.G711E	SIDM01056	Breast Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6087
p.G711E	ACH-000330	Breast Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6087
p.G711E	EFM-19	breast	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6087
p.T425P	TCGA-QK-A6VB	HNSC	TCGA	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7031
p.T425P	DO219054	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7031
p.T978I	TCGA-TQ-A7RF	LGG	TCGA	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation blocking phosphorylation signal	0.6111
p.T978I	DO223685	LGG	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation blocking phosphorylation signal	0.6111
p.A934V	TCGA-VQ-A8PB	STAD	TCGA	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.25
p.A934V	TCGA-VQ-A8PB	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.A934V	DO51766	STAD	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.25
p.A934V	DO51766	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.T932I	TCGA-VQ-A8PE	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8189
p.T932I	DO51769	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.8189
p.A617T	TCGA-VQ-A8PP	STAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.3056
p.A617T	DO51774	STAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.3056
p.A942G	TCGA-VQ-AA64	STAD	TCGA	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.A942G	DO222381	STAD	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0556
p.G756R	TCGA-YD-A9TA	SKCM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.6457
p.G756R	DO229462	SKCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.6457
p.G756R	DO219503	SKCM	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.6457
p.L344V	TCGA-Z6-AAPN	ESCA	TCGA	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1111
p.L344V	TCGA-Z6-AAPN	ESCA	TCGA	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1944
p.T712S	TCGA-ZB-A966	THYM	TCGA	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6005
p.T625M	TCGA-ZM-AA0N	TGCT	TCGA	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation blocking phosphorylation signal	0.5278
p.K599E	DO48444	BLCA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599E	DO228918	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599E	DO228923	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599E	DO228978	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599E	DO228985	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K599E	DO229058	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.T724S	DO224680	BRCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.K841R	DO229377	BTCA	ICGC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation blocking ubiquitination signal	0.6111
p.K841R	DO229377	BTCA	ICGC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation blocking ubiquitination signal	0.5
p.T975A	DO8264	COAD	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.25
p.T597P	DO224628	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.8142
p.T597P	DO228961	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.8142
p.T597P	DO228985	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.8142
p.T597P	DO231186	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.8142
p.T597P	DO228011	SKCA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.8142
p.T511P	DO222718	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.8142
p.T511P	DO222839	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.8142
p.T511P	DO230548	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.8142
p.T511P	DO231067	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.8142
p.C746S	DO229010	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1944
p.C746S	DO229010	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.C746S	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.C746S	DO229013	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1944
p.C746S	DO229013	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.C746S	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.C746S	DO229016	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1944
p.C746S	DO229016	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.C746S	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.C746S	DO229003	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1944
p.C746S	DO229003	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.C746S	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.C746S	DO229005	COCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1944
p.C746S	DO229005	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1111
p.C746S	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.T604A	DO229013	COCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.T604A	DO229013	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1389
p.T604A	DO229016	COCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.T604A	DO229016	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1389
p.T604A	DO229047	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.T604A	DO229047	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1389
p.T604A	DO52365	LUSC	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1667
p.T604A	DO52365	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1389
p.A343V	DO228123	EOPC	ICGC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1389
p.A343V	DO228123	EOPC	ICGC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.T401P	DO227451	EOPC	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7031
p.T401P	DO228909	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7031
p.T401P	DO229048	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7031
p.T401P	DO229052	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7031
p.K918R	DO233267	GACA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.2778
p.K918R	DO233267	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.1667
p.G809E	DO233705	GACA	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.G809E	DO233705	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.G809E	DO227501	LAML	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.G809E	DO227501	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.G809E	DO227513	LAML	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.G809E	DO227513	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.G809E	DO224619	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.G809E	DO224619	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.G809E	DO229208	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.2778
p.G809E	DO229208	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.3056
p.A934T	DO233882	GACA	ICGC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.25
p.A934T	DO233882	GACA	ICGC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.A934T	NCI-H1417	lung	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.25
p.A934T	NCI-H1417	lung	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.2778
p.S427P	DO20770	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation blocking phosphorylation signal	0.5
p.S427P	DO20770	KIRP	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation blocking phosphorylation signal	0.7222
p.T704P	DO227501	LAML	ICGC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.7031
p.Q959E	DO231984	LICA	ICGC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.1667
p.Q959E	DO231984	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.3056
p.T757P	DO228915	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.8142
p.G756E	DO228915	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.6087
p.G756E	DO229051	LICA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation altering degron motif	0.6087
p.L733P	DO228945	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.L733P	DO228945	LICA	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.L733P	DO224610	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.3056
p.L733P	DO224610	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.P600S	DO228944	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0556
p.P600S	DO228944	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.25
p.A585S	DO228944	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.A405S	DO228948	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A405S	DO228948	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.1111
p.A405S	DO229052	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A405S	DO229052	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.1111
p.L226F	DO229025	LICA	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.1389
p.L226F	DO229025	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0556
p.K232N	DO229024	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation substituting flanking lysine	0.3333
p.E703D	DO229031	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.5647
p.P393L	DO229050	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1389
p.P393L	DO229050	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.P378T	DO229051	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.P378T	DO231114	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.E419K	DO229058	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.2778
p.E419K	DO229058	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2778
p.D237Y	DO229009	LICA	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.6214
p.D237Y	DO229009	LICA	ICGC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.6214
p.P791L	DO23198	LINC	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.0556
p.P531S	DO231722	LINC	ICGC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation altering degron motif	0.5641
p.T417P	DO23434	LINC	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7031
p.T417P	DO229184	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7031
p.T417P	DO229084	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7031
p.T417P	DO229087	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7031
p.E740G	DO50827	LIRI	ICGC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.E740G	DO50827	LIRI	ICGC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.3056
p.A507S	DO230554	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7588
p.A507S	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7588
p.S515A	DO230554	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.S515A	DO230554	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1111
p.L624P	DO228231	MALY	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO230552	PRAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO219876	SKCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO219875	SKCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO229259	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO229213	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO229232	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.L624P	DO229248	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1111
p.A329T	DO228496	MALY	ICGC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.2778
p.A329T	DO228496	MALY	ICGC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.1667
p.KG779KW	DO222595	MELA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.8064
p.T616P	DO48919	PBCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7031
p.A705T	DO232761	PBCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.3056
p.A705T	DO232761	PBCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.3056
p.T234I	DO51953	PRAD	ICGC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.5966
p.G780R	DO218863	SKCA	ICGC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation altering degron motif	0.6457
p.K504E	DO229216	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation substituting flanking lysine	0.3611
p.P432T	DO229234	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1389
p.E536K	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0833
p.E536K	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.2778
p.E536K	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.2778
p.A523T	DO231353	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.7139
p.P537S	SIDM01304	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0556
p.P537S	SIDM01304	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.25
p.P537S	SIDM01304	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.3056
p.P537S	SIDM00803	Kidney Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0556
p.P537S	SIDM00803	Kidney Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.25
p.P537S	SIDM00803	Kidney Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.3056
p.E772G	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	SIDM01318	Hepatocellular Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	SIDM01451	Pancreatic Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	ACH-001318	Liver Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E336K	SIDM00215	Colorectal Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00215	Colorectal Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00586	Hepatocellular Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00586	Hepatocellular Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00473	Oral Cavity Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00473	Oral Cavity Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00463	T-Lymphoblastic Leukemia	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00908	Non-Cancerous	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00908	Non-Cancerous	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00619	Thyroid Gland Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00619	Thyroid Gland Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00522	Small Cell Lung Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00522	Small Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM01217	Other Blood Cancers	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM01217	Other Blood Cancers	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM01617	Endometrial Carcinoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM01617	Endometrial Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM01577	Plasma Cell Myeloma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM01577	Plasma Cell Myeloma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM01574	Plasma Cell Myeloma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM01574	Plasma Cell Myeloma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.E336K	SIDM01756	Chronic Myelogenous Leukemia	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation altering degron motif	0.7022
p.E336K	SIDM01756	Chronic Myelogenous Leukemia	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.591
p.A382E	SIDM00845	Burkitt's Lymphoma	GDSC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7701
p.A382E	SIDM00035	Thyroid Gland Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7701
p.P767T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.0556
p.P767T	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.P767T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.0556
p.P767T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.P767T	ACH-000706	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.0556
p.P767T	ACH-000706	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.P767T	EKVX	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.0556
p.P767T	EKVX	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.A750T	SIDM00392	Melanoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00392	Melanoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM00025	Head and Neck Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00025	Head and Neck Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM00789	Colorectal Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00789	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM01168	Colorectal Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM01168	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM00966	Ovarian Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00966	Ovarian Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM00112	Kidney Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00112	Kidney Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A750T	SIDM00918	Ovarian Carcinoma	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.3056
p.A750T	SIDM00918	Ovarian Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1944
p.A413S	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7588
p.A413S	D-542MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7588
p.E764K	SIDM00007	Other Solid Cancers	GDSC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764K	ACH-001550	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.E764K	MCC13	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.1389
p.T811I	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.5966
p.T811I	ACH-000021	Lung Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.5966
p.T811I	NCI-H1693	lung	COSMIC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.5966
p.S815T	SIDM00669	Pancreatic Carcinoma	GDSC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation blocking phosphorylation signal	0.6389
p.S815T	SIDM00669	Pancreatic Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation blocking phosphorylation signal	0.5556
p.S815T	SIDM00669	Pancreatic Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation blocking phosphorylation signal	0.75
p.S815T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation blocking phosphorylation signal	0.6389
p.S815T	SIDM00721	Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation blocking phosphorylation signal	0.5556
p.S815T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation blocking phosphorylation signal	0.75
p.P236R	SIDM00761	Small Cell Lung Carcinoma	GDSC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7512
p.P236R	SIDM00761	Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7512
p.P236R	ACH-000752	Lung Cancer	CCLE	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7512
p.P236R	ACH-000752	Lung Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7512
p.P236R	NCI-H196	lung	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7512
p.P236R	NCI-H196	lung	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7512
p.T814S	SIDM00899	Pancreatic Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.7116
p.T814S	ACH-000222	Pancreatic Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.7116
p.T814S	AsPC-1	pancreas	COSMIC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation altering degron motif	0.7116
p.A343T	SIDM01106	Melanoma	GDSC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1389
p.A343T	SIDM01106	Melanoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.A343T	ACH-000822	Skin Cancer	CCLE	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1389
p.A343T	ACH-000822	Skin Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.A343T	SK-MEL-24	skin	COSMIC	PTPKAE	DEG_SCF_FBW7_2	331:336	Mutation rewiring degron network	0.1389
p.A343T	SK-MEL-24	skin	COSMIC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.P503H	SIDM00282	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.P503H	ACH-000998	Colon/Colorectal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.P503H	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.T339N	SIDM00963	Breast Carcinoma	GDSC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7055
p.T339N	ACH-000927	Breast Cancer	CCLE	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7055
p.T339N	BT-474	breast	COSMIC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7055
p.T930A	SIDM00487	Colorectal Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation altering degron motif	0.6028
p.T930A	SIDM00487	Colorectal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7139
p.T930A	ACH-000963	Colon/Colorectal Cancer	CCLE	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation altering degron motif	0.6028
p.T930A	ACH-000963	Colon/Colorectal Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7139
p.T930A	CCK-81	large intestine	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation altering degron motif	0.6028
p.T930A	CCK-81	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation altering degron motif	0.7139
p.T415A	SIDM00498	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7139
p.T424I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7078
p.T424I	ACH-000951	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7078
p.K796E	SIDM00218	Thyroid Gland Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation substituting flanking lysine	0.25
p.K796E	SIDM00900	Non-Cancerous	GDSC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation substituting flanking lysine	0.25
p.T517I	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.T517I	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1667
p.T517I	ACH-000451	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.T517I	ACH-000451	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1667
p.T517I	ACH-001547	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1667
p.T517I	ACH-001547	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1667
p.S962C	SIDM00679	Cervical Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.8652
p.S962C	ACH-001525	Cervical Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.8652
p.S962C	HT-3	cervix	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.8652
p.K936M	SIDM00220	Ovarian Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.3056
p.K936M	SIDM00220	Ovarian Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.3333
p.K936M	OC-314	ovary	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.3056
p.K936M	OC-314	ovary	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.3333
p.T957S	SIDM00503	Gastric Carcinoma	GDSC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.1111
p.T957S	SIDM00503	Gastric Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.25
p.T957S	FU97	stomach	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.1111
p.T957S	FU97	stomach	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.25
p.T361I	SIDM01173	Rhabdomyosarcoma	GDSC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation altering degron motif	0.7078
p.P236H	SIDM00980	Gastric Carcinoma	GDSC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7694
p.P236H	SIDM00980	Gastric Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7694
p.P236H	ACH-000948	Gastric Cancer	CCLE	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7694
p.P236H	ACH-000948	Gastric Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7694
p.P236H	23132-87	stomach	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7694
p.P236H	23132-87	stomach	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7694
p.K936T	SIDM01588	Endometrial Carcinoma	GDSC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.3056
p.K936T	SIDM01588	Endometrial Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.3333
p.K936T	ACH-000993	Endometrial/Uterine Cancer	CCLE	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.3056
p.K936T	ACH-000993	Endometrial/Uterine Cancer	CCLE	PETTT	DEG_SPOP_SBC_1	928:932	Mutation substituting flanking lysine	0.3333
p.E357K	SIDM01443	Gastric Carcinoma	GDSC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.3056
p.E357K	ACH-000344	Gastric Cancer	CCLE	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.3056
p.P506S	SIDM01443	Gastric Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.3056
p.T542P	ACH-000411	Kidney Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7031
p.T542P	ACH-001347	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7031
p.T542P	ACH-001430	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7031
p.S544P	ACH-000693	Esophageal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	530:534	Mutation blocking phosphorylation signal	0.5
p.S544P	ACH-000693	Esophageal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	538:542	Mutation blocking phosphorylation signal	0.7222
p.S544P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation blocking phosphorylation signal	0.5
p.S544P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation blocking phosphorylation signal	0.7222
p.E772K	ACH-000916	Lung Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.E772K	NCI-H1573	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.S855P	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.P789R	ACH-001232	Brain Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1111
p.G711R	ACH-001521	Skin Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation altering degron motif	0.6457
p.T241P	ACH-001669	Leukemia	CCLE	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.2778
p.T241P	ACH-001669	Leukemia	CCLE	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.3056
p.T241P	ACH-002238	Leukemia	CCLE	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.2778
p.T241P	ACH-002238	Leukemia	CCLE	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.3056
p.T241P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.2778
p.T241P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.3056
p.K394N	ACH-002027	Endometrial/Uterine Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	382:386	Mutation substituting flanking lysine	0.2222
p.K394N	ACH-002027	Endometrial/Uterine Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	397:401	Mutation substituting flanking lysine	0.3611
p.E719K	ACH-002287	Colon/Colorectal Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1389
p.E719K	NCI-H630	large intestine	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.1389
p.T742A	ACH-002287	Colon/Colorectal Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.6028
p.T742A	NCI-H630	large intestine	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.6028
p.E788K	ACH-002396	Bone Cancer	CCLE	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1389
p.E788K	Sarc9371	bone	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1389
p.E721G	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.E721G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.E721G	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.T601N	D-566MG	central nervous system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0833
p.T601N	D-566MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2222
p.P603T	SK-NEP-1	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	SK-NEP-1	kidney	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P603T	451Lu	skin	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	451Lu	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P603T	HCC-15	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	HCC-15	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P603T	U031	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	U031	kidney	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P603T	COLO-824	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	COLO-824	breast	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P603T	MFE-319	endometrium	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.P603T	MFE-319	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.E729G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729G	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E729G	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.T837A	CCK-81	large intestine	COSMIC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.0556
p.T768I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1389
p.T435A	A172	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	COLO-684	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	EW-24	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	KYSE-70	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	SK-PN-DW	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	ABC-1	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	DEL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.T435A	UM-UC-3	urinary tract	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.P696T	HCC-15	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	HCC-15	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P696T	SK-NEP-1	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	SK-NEP-1	kidney	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P696T	COLO-824	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	COLO-824	breast	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P696T	U031	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	U031	kidney	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P696T	MFE-319	endometrium	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	MFE-319	endometrium	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P696T	451Lu	skin	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.2778
p.P696T	451Lu	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P732T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.P732T	SK-MEL-30	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.P732T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.P732T	UACC-62	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.P732T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2778
p.P732T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0833
p.T385A	SK-PN-DW	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	A172	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	ABC-1	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	UM-UC-3	urinary tract	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	KYSE-70	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	DEL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	EW-24	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T385A	COLO-684	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.P355R	TE-6	oesophagus	COSMIC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.T585P	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1111
p.P724T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.P724T	EKVX	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.P724T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.P724T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0556
p.S869C	HT-3	cervix	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.1667
p.A540T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7139
p.A540T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7139
p.T521I	KINGS-1	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0556
p.T521I	KINGS-1	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2778
p.T521I	KINGS-1	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.0833
p.T616A	G-292_Clone_A141B1	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T616A	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T616A	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T616A	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T616A	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.P597L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation altering degron motif	0.7582
p.T551N	D-566MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.0833
p.T535P	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation substituting flanking lysine	0.2222
p.T535P	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation substituting flanking lysine	0.3611
p.A598T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.S501P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation blocking phosphorylation signal	0.6111
p.S510A	HeLa	cervix	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7588
p.S510A	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7588
p.A590T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation substituting flanking lysine	0.3611
p.A590T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation substituting flanking lysine	0.3611
p.P613L	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7582
p.P613L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7582
p.T619P	JHH-7	liver	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.25
p.P773T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.2778
p.P773T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.2778
p.P773T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.2778
p.T773S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.2778
p.P722T	UACC-62	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P722T	SK-MEL-30	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.P722T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0556
p.T951A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0833
p.A975T	LS-411N	large intestine	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.25
p.E587Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.A973T	LS-411N	large intestine	COSMIC	TQDTTPFK	DEG_SCF_SKP2-CKS1_1	965:972	Mutation rewiring degron network	0.3056
p.A973T	LS-411N	large intestine	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.0833
p.A250T	SK-MEL-24	skin	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.0556
p.T527P	KG-1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.7031
p.E731G	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.3611
p.E731G	SK-MEL-30	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation substituting flanking lysine	0.1667
p.E731G	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.3611
p.E731G	UACC-62	skin	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation substituting flanking lysine	0.1667
p.E731G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.3611
p.E731G	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation substituting flanking lysine	0.1667
p.T614A	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T614A	G-292_Clone_A141B1	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T614A	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T614A	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T614A	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7139
p.T858A	EN	endometrium	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation altering degron motif	0.7139
p.T526P	JHH-7	liver	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.7031
p.P730T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2222
p.P730T	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2222
p.P730T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.2222
p.T246N	BT-474	breast	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation rewiring degron network	0.1389
p.T246N	BT-474	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation rewiring degron network	0.1667
p.T701A	NCI-H630	large intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.7139
p.E695K	Sarc9371	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.25
p.P410H	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation substituting flanking lysine	0.1944
p.P410H	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation substituting flanking lysine	0.3611
p.A520S	KM12	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation substituting flanking lysine	0.1944
p.A520S	KM12	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation substituting flanking lysine	0.3611
p.A520S	KM12	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation substituting flanking lysine	0.1667
p.T434P	KG-1	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.E589Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2222
p.T721S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.A372S	D-542MG	central nervous system	COSMIC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation substituting flanking lysine	0.1667
p.A372S	D-542MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	382:386	Mutation substituting flanking lysine	0.1667
p.S512A	HeLa	cervix	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.3056
p.S512A	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.3056
p.K590E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation substituting flanking lysine	0.3611
p.K399E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7022
p.G618E	EFM-19	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.2778
p.T914S	FU97	stomach	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.0556
p.T953A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation rewiring degron network	0.1389
p.S964L	NCI-H810	lung	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7667
p.T770I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.1944
p.E747K	Sarc9371	bone	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	751:757	Mutation rewiring degron network	0.2222
p.E747K	Sarc9371	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.0833
p.E747K	Sarc9371	bone	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2778
p.E824D	D-283MED	central nervous system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation altering degron motif	0.6758
p.A518S	KM12	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation blocking phosphorylation signal	0.5833
p.A518S	KM12	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation blocking phosphorylation signal	0.6389
p.T699A	NCI-H630	large intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.6028
p.E745K	Sarc9371	bone	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation altering degron motif	0.7022
p.S921C	HT-3	cervix	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.25
p.S921C	HT-3	cervix	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1389
p.P615L	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7582
p.P615L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7582
p.N238S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7069
p.N238S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7069
p.E626K	NCI-H630	large intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0556
p.K538E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7022
p.E537Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0556
p.E537Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	530:534	Mutation rewiring degron network	0.25
p.E537Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.3056
p.E721K	MCC13	skin	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation rewiring degron network	0.0833
p.T608S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.2778
p.S503P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.E612K	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7022
p.E612K	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7022
p.T718I	NCI-H1693	lung	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	706:712	Mutation substituting flanking lysine	0.2778
p.T860A	EN	endometrium	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation altering degron motif	0.7139
p.T916S	FU97	stomach	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation substituting flanking lysine	0.2222
p.S919C	HT-3	cervix	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.1944
p.S919C	HT-3	cervix	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.0833
p.N236S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VTTPDTS	DEG_SCF_FBW7_1	233:239	Mutation altering degron motif	0.7069
p.N236S	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PDTST	DEG_SPOP_SBC_1	236:240	Mutation altering degron motif	0.7069
p.P405R	TE-6	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.P405R	TE-6	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.1111
p.T864S	FU97	stomach	COSMIC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation substituting flanking lysine	0.1944
p.T963A	EN	endometrium	COSMIC	VTSTT	DEG_SPOP_SBC_1	960:964	Mutation altering degron motif	0.7139
p.T771S	AsPC-1	pancreas	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation substituting flanking lysine	0.3333
p.E614K	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7022
p.E614K	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7022
p.T808A	EN	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	803:807	Mutation rewiring degron network	0.3056
p.T808A	EN	endometrium	COSMIC	PTSTT	DEG_SPOP_SBC_1	810:814	Mutation rewiring degron network	0.2778
p.E729K	NCI-H1573	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation rewiring degron network	0.1944
p.E731K	NCI-H1573	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.3611
p.E731K	NCI-H1573	lung	COSMIC	PTSTT	DEG_SPOP_SBC_1	741:745	Mutation substituting flanking lysine	0.1667
p.A592T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.A592T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.3056
p.T523I	KINGS-1	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.7078
p.A370S	D-542MG	central nervous system	COSMIC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1111
p.E865D	D-283MED	central nervous system	COSMIC	VSTPTTT	DEG_SCF_FBW7_1	857:863	Mutation rewiring degron network	0.2778
p.E865D	D-283MED	central nervous system	COSMIC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0556
p.E772D	D-283MED	central nervous system	COSMIC	PTTPKGT	DEG_SCF_FBW7_1	775:781	Mutation rewiring degron network	0.25
p.T610S	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation altering degron motif	0.7116
p.K401E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.7022
p.T603N	D-566MG	central nervous system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.1389
p.T603N	D-566MG	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.A923T	LS-411N	large intestine	COSMIC	LRTTPETT	DEG_SCF_FBW7_1	924:931	Mutation rewiring degron network	0.3056
p.A923T	LS-411N	large intestine	COSMIC	PETTT	DEG_SPOP_SBC_1	928:932	Mutation rewiring degron network	0.1944
p.P547L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1944
p.E822D	D-283MED	central nervous system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	820:826	Mutation altering degron motif	0.6758
p.A548T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.A414S	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation altering degron motif	0.7588
p.P726T	EKVX	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	734:738	Mutation substituting flanking lysine	0.2222
p.T587P	CW-2	large intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1667
p.P599L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.2778
p.K349E	SK-GT-2	stomach	COSMIC	AETTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0556
p.K349E	SK-GT-2	stomach	COSMIC	PASTT	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0833
p.P407R	TE-6	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1667
p.P407R	TE-6	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	413:417	Mutation rewiring degron network	0.1667
p.K588E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.1944
p.A600T	NCI-H1693	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	610:616	Mutation rewiring degron network	0.0556
p.A600T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	593:597	Mutation rewiring degron network	0.25
p.K843M	OC-314	ovary	COSMIC	PETPPPT	DEG_SCF_FBW7_1	847:853	Mutation rewiring degron network	0.2222
p.K843M	OC-314	ovary	COSMIC	PPTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRG4

UniProt ID: Q92954

Entrez ID: 10216

Protein name: Proteoglycan 4 (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Cleaved into: Proteoglycan 4 C-terminal part]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRG4 in