DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 820:826

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 111.2286

COIL: 0.9584

CONS_SCORE: 0.4101

DSS_SCORE: 0.8099

HELIX: 0.0137

FCONS_SCORE: 1.3092

RIG_SCORE: 0.5529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P836R	TCGA-55-7910	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.P836R	DO23669	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.P818H	TCGA-86-8073	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P818H	DO23624	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.K817T	TCGA-AX-A0J0	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.3611
p.K817T	DO41133	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.3611
p.E833K	TCGA-EE-A29R	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.E833K	TCGA-ER-A194	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.E833K	DO37448	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.E833K	DO47646	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.S815T	SIDM00669	Pancreatic Carcinoma	GDSC	PTTPKET	DEG_SCF_FBW7_1	0.6389
p.S815T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTTPKET	DEG_SCF_FBW7_1	0.6389
p.E824D	D-283MED	central_nervous_system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.6758
p.E822D	D-283MED	central_nervous_system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons