DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 698:704

E3 ligase: FBXW7

DEGRON score: 0.8931

ASA_SCORE: 112.9714

COIL: 0.9604

CONS_SCORE: 0.2471

DSS_SCORE: 0.8324

HELIX: 0.015

FCONS_SCORE: 0.9173

RIG_SCORE: 0.5568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A697V	TCGA-06-5416	GBM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.3056
p.A697V	DO10880	GBM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.3056
p.P698A	TCGA-ER-A19B	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.7503
p.P698A	DO47491	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.7503
p.T704P	DO227501	LAML	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.7031
p.E703D	DO229031	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.5647
p.A705T	DO232761	PBCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.3056
p.P696T	HCC-15	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P696T	SK-NEP-1	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P696T	COLO-824	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P696T	U031	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P696T	MFE-319	endometrium	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P696T	451Lu	skin	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.T701A	NCI-H630	large_intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.E695K	Sarc9371	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.25
p.T699A	NCI-H630	large_intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.6028

DegronMD: protein-targeted degradation, mutation and drug response to degrons