DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SCF_FBW7_1

Location: 610:616

E3 ligase: FBXW7

DEGRON score: 0.9603

ASA_SCORE: 112.9286

COIL: 0.962

CONS_SCORE: 0.3201

DSS_SCORE: 0.8047

HELIX: 0.0144

FCONS_SCORE: 0.9118

RIG_SCORE: 0.5679

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E615K	TCGA-55-8094	LUAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.591
p.E615K	TCGA-W3-AA1Q	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.591
p.E615K	DO24150	LUAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.591
p.E615K	DO219487	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.591
p.P605H	TCGA-A4-7583	KIRP	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.1944
p.P605H	DO20870	KIRP	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1944
p.K614N	TCGA-AP-A0LM	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.5806
p.K614N	DO43306	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.5806
p.P605L	TCGA-AX-A1CE	UCEC	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.1944
p.P605L	DO42280	UCEC	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1944
p.P626L	TCGA-EI-6510	READ	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.P626L	DO36387	READ	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.P613R	TCGA-GN-A26D	SKCM	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.7512
p.P613R	DO37480	SKCM	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.7512
p.A617T	TCGA-VQ-A8PP	STAD	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.3056
p.A617T	DO51774	STAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.3056
p.T625M	TCGA-ZM-AA0N	TGCT	TCGA	PTTPKET	DEG_SCF_FBW7_1	0.5278
p.T604A	DO229013	COCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1667
p.T604A	DO229016	COCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1667
p.T604A	DO229047	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1667
p.T604A	DO52365	LUSC	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1667
p.P600S	DO228944	LICA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.L624P	DO228231	MALY	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO230552	PRAD	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO219876	SKCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO219875	SKCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO229259	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO229213	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO229232	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.L624P	DO229248	THCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.1111
p.T616P	DO48919	PBCA	ICGC	PTTPKET	DEG_SCF_FBW7_1	0.7031
p.T601N	D-566MG	central_nervous_system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.0833
p.P603T	SK-NEP-1	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.P603T	451Lu	skin	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.P603T	HCC-15	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.P603T	U031	kidney	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.P603T	COLO-824	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.P603T	MFE-319	endometrium	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.T616A	G-292_Clone_A141B1	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T616A	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T616A	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T616A	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T616A	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.P613L	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7582
p.P613L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7582
p.T619P	JHH-7	liver	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.25
p.T614A	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T614A	G-292_Clone_A141B1	bone	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T614A	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T614A	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.T614A	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7139
p.G618E	EFM-19	breast	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.P615L	SU-DHL-8	NS	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7582
p.P615L	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7582
p.E626K	NCI-H630	large_intestine	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.0556
p.T608S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.2778
p.E612K	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7022
p.E612K	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7022
p.E614K	NCI-N87	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7022
p.E614K	SK-GT-2	stomach	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7022
p.T610S	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.7116
p.T603N	D-566MG	central_nervous_system	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.1389
p.A600T	NCI-H1693	lung	COSMIC	PTTPKET	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPKET

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of PTTPKET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	610:616	PTTPKET	FBXW7	0.9603	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	698:704	PTTPKET	FBXW7	0.8931	More...
Q92954	Proteoglycan 4	DEG_SCF_FBW7_1	820:826	PTTPKET	FBXW7	0.9983	More...