DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 810:814

E3 ligase: SPOP

DEGRON score: 0.9461

ASA_SCORE: 95.02

COIL: 0.9544

CONS_SCORE: 0.1962

DSS_SCORE: 0.79

HELIX: 0.0164

FCONS_SCORE: 0.749

RIG_SCORE: 0.531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P818H	TCGA-86-8073	LUAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2222
p.P818H	DO23624	LUAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.K817T	TCGA-AX-A0J0	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3611
p.K817T	DO41133	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3611
p.E801K	TCGA-D1-A17Q	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0833
p.E801K	TCGA-W3-AA1V	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0833
p.E801K	DO51276	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.E801K	DO41903	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0833
p.G809E	DO233705	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.G809E	DO227501	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.G809E	DO227513	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.G809E	DO224619	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.G809E	DO229208	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.T811I	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.5966
p.T811I	ACH-000021	Lung Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.5966
p.T811I	NCI-H1693	lung	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.5966
p.S815T	SIDM00669	Pancreatic Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.75
p.S815T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.75
p.T814S	SIDM00899	Pancreatic Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.7116
p.T814S	ACH-000222	Pancreatic Cancer	CCLE	PTSTT	DEG_SPOP_SBC_1	0.7116
p.T814S	AsPC-1	pancreas	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.7116
p.T808A	EN	endometrium	COSMIC	PTSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons