DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1539:1543

E3 ligase: SPOP

DEGRON score: 0.9933

ASA_SCORE: 97.22

COIL: 0.95

CONS_SCORE: 0.1891

DSS_SCORE: 0.7498

HELIX: 0.0114

FCONS_SCORE: 1.0129

RIG_SCORE: 0.6263

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1529N	TCGA-EE-A2M5	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.0556
p.T1529N	DO222423	MELA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.T1529N	DO37425	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.P1539T	DO224735	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.P1539T	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.P1539T	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.P1539T	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.P1539T	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.P1539T	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.7031
p.T1540N	DO224735	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO224757	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1540N	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.5944
p.T1544M	DO222765	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3056
p.R1553G	DO229010	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229013	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229016	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229003	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229005	COCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO233074	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO51040	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO51028	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO51004	LAML	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO52377	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO52391	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO52389	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229180	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229199	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229234	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.R1553G	DO229248	THCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.0556
p.S1551R	DO233941	GACA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTSTT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of PTSTT