DegronMD

Uniprot ID: Q96LM5

Source protein: Uncharacterized protein C4orf45

Source gene: C4orf45

Class: DEG_SPOP_SBC_1

Location: 9:13

E3 ligase: SPOP

DEGRON score: 0.8223

ASA_SCORE: 75.78

COIL: 0.8814

CONS_SCORE: 0.3358

DSS_SCORE: 0.3324

HELIX: 0.0434

FCONS_SCORE: 0.6112

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T12N	TCGA-5U-AB0D	THYM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.7055
p.Q17E	TCGA-66-2785	LUSC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.2222
p.Q17E	DO26520	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.2222
p.I19V	TCGA-AX-A1CE	UCEC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1667
p.I19V	DO42280	UCEC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.M18I	TCGA-BF-AAP7	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	0.1944
p.M18I	DO219472	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1944
p.K16N	TCGA-MI-A75I	LIHC	TCGA	PTSTT	DEG_SPOP_SBC_1	0.3611
p.K16N	DO49712	LIHC	ICGC	PTSTT	DEG_SPOP_SBC_1	0.3611
p.A2T	TCGA-VQ-A8P2	STAD	TCGA	PTSTT	DEG_SPOP_SBC_1	0.25
p.A2T	DO51761	STAD	ICGC	PTSTT	DEG_SPOP_SBC_1	0.25
p.I19T	DO222780	BTCA	ICGC	PTSTT	DEG_SPOP_SBC_1	0.1667
p.V4I	SIDM00783	Colorectal Carcinoma	GDSC	PTSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	261:265	PTSTT	SPOP	0.9957	More...
O95274	Ly6/PLAUR domain-containing protein 3	DEG_SPOP_SBC_1	265:269	PTSTT	SPOP	0.6057	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1269:1273	PTSTT	SPOP	0.8061	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3449:3453	PTSTT	SPOP	0.9952	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1539:1543	PTSTT	SPOP	0.9933	More...
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1932:1936	PTSTT	SPOP	0.7189	More...
Q8IZF6	Adhesion G-protein coupled receptor G4	DEG_SPOP_SBC_1	638:642	PTSTT	SPOP	0.5747	More...
Q8NFY4	Semaphorin-6D	DEG_SPOP_SBC_1	573:577	PTSTT	SPOP	0.9915	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	741:745	PTSTT	SPOP	0.9471	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	810:814	PTSTT	SPOP	0.9461	More...
Q96LM5	Uncharacterized protein C4orf45	DEG_SPOP_SBC_1	9:13	PTSTT	SPOP	0.8223	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	795:799	PTSTT	SPOP	0.9575	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	1885:1889	PTSTT	SPOP	0.9877	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2005:2009	PTSTT	SPOP	0.9831	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2046:2050	PTSTT	SPOP	0.9546	More...
Q9UBL0	cAMP-regulated phosphoprotein 21	DEG_SPOP_SBC_1	647:651	PTSTT	SPOP	0.7583	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons